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IOLE_SALTY
ID   IOLE_SALTY              Reviewed;         301 AA.
AC   Q8ZK58;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Inosose dehydratase {ECO:0000255|HAMAP-Rule:MF_01672};
DE            EC=4.2.1.44 {ECO:0000255|HAMAP-Rule:MF_01672};
DE   AltName: Full=2-keto-myo-inositol dehydratase {ECO:0000255|HAMAP-Rule:MF_01672};
DE            Short=2KMI dehydratase {ECO:0000255|HAMAP-Rule:MF_01672};
GN   Name=iolE {ECO:0000255|HAMAP-Rule:MF_01672}; OrderedLocusNames=STM4424;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Catalyzes the dehydration of inosose (2-keto-myo-inositol,
CC       2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-
CC       trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).
CC       {ECO:0000255|HAMAP-Rule:MF_01672}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione +
CC         H2O; Xref=Rhea:RHEA:14065, ChEBI:CHEBI:15377, ChEBI:CHEBI:17811,
CC         ChEBI:CHEBI:28446; EC=4.2.1.44; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01672};
CC   -!- COFACTOR:
CC       Name=glutathione; Xref=ChEBI:CHEBI:57925;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01672};
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01672};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01672};
CC   -!- SIMILARITY: Belongs to the IolE/MocC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01672}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL23244.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE006468; AAL23244.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_463285.3; NC_003197.2.
DR   AlphaFoldDB; Q8ZK58; -.
DR   SMR; Q8ZK58; -.
DR   STRING; 99287.STM4424; -.
DR   PaxDb; Q8ZK58; -.
DR   EnsemblBacteria; AAL23244; AAL23244; STM4424.
DR   GeneID; 1255950; -.
DR   KEGG; stm:STM4424; -.
DR   PATRIC; fig|99287.12.peg.4652; -.
DR   HOGENOM; CLU_059523_0_0_6; -.
DR   OMA; YDSRPEL; -.
DR   PhylomeDB; Q8ZK58; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0050114; F:myo-inosose-2 dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01672; IolE; 1.
DR   InterPro; IPR023952; IolE.
DR   InterPro; IPR030823; IolE/MocC.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR04379; myo_inos_iolE; 1.
PE   3: Inferred from homology;
KW   Cobalt; Lyase; Manganese; Reference proteome.
FT   CHAIN           1..301
FT                   /note="Inosose dehydratase"
FT                   /id="PRO_0000352379"
SQ   SEQUENCE   301 AA;  33876 MW;  64B3BE84E3958940 CRC64;
     MYNVKKSIKL GIAPIGWRND DIPEIGKENT YKQILSDAAL TGFSGTEVGG CYPQDPAELN
     KELMLRGLEI PGQWFSSFII RDGIASAMNA FEQHCAYLQA IHAYVAVVSE QTYSIQGIID
     KCVYTEKPNF SDSEWQLLCE GLNALGKIAN AHGLKLAFHH HMGTGVQTLP EVDRLMENTD
     PQFVHLLFDT GHIYVSDGDV MPLLSKHFDR IKHVHFKDVR NEKLKACRLA KKSFLNSFLD
     GVFTVPGDGN IDFKSVLAYL VGHQYSGWIV VEAEQDPKKY NPLEYAQKGK KHIDELLKNY
     L
 
 
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