ID   IOLG1_PAEAT             Reviewed;         337 AA.
AC   A1R665;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Inositol 2-dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_01671};
DE            EC=1.1.1.18 {ECO:0000255|HAMAP-Rule:MF_01671};
DE   AltName: Full=Myo-inositol 2-dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_01671};
DE            Short=MI 2-dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_01671};
GN   Name=iolG1 {ECO:0000255|HAMAP-Rule:MF_01671}; OrderedLocusNames=AAur_1982;
OS   Paenarthrobacter aurescens (strain TC1).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Paenarthrobacter.
OX   NCBI_TaxID=290340;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TC1;
RX   PubMed=17194220; DOI=10.1371/journal.pgen.0020214;
RA   Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B.,
RA   Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V.,
RA   Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.;
RT   "Secrets of soil survival revealed by the genome sequence of Arthrobacter
RT   aurescens TC1.";
RL   PLoS Genet. 2:2094-2106(2006).
CC   -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-
CC       inositol (2KMI or 2-inosose). {ECO:0000255|HAMAP-Rule:MF_01671}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose;
CC         Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268,
CC         ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01671};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01671}.
CC   -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01671}.
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DR   EMBL; CP000474; ABM08500.1; -; Genomic_DNA.
DR   RefSeq; WP_011774671.1; NC_008711.1.
DR   AlphaFoldDB; A1R665; -.
DR   SMR; A1R665; -.
DR   STRING; 290340.AAur_1982; -.
DR   EnsemblBacteria; ABM08500; ABM08500; AAur_1982.
DR   KEGG; aau:AAur_1982; -.
DR   eggNOG; COG0673; Bacteria.
DR   HOGENOM; CLU_023194_0_1_11; -.
DR   OMA; RKPVMCE; -.
DR   OrthoDB; 1465613at2; -.
DR   Proteomes; UP000000637; Chromosome.
DR   GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01671; IolG; 1.
DR   InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR   InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR   InterPro; IPR023794; MI/DCI_dehydrogenase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..337
FT                   /note="Inositol 2-dehydrogenase 1"
FT                   /id="PRO_0000352551"
SQ   SEQUENCE   337 AA;  36338 MW;  380853AF1F658331 CRC64;
     MTKTLRVAVI GAGRMGADHI KRLSTRIHGA EVAAVVDVDL ARAQAAIEGI DRAVALASAD
     EALNNGDVNA VLIATPGFLH EEILYKALEK DFPILCEKPL TPDAGSAWKV VQAEQALGHK
     RIQVGFMRRF DAEYSALGAI IRNSELGELL MLHHQHRNPS TPEGFTNEML INDSVVHEFD
     AIRFFTGEEI TSVQVRLGKP TRSAPSGQHD PQHVLLETES GVLADVEIYV NAKFGYQVAT
     QASFEEGIVS IGSDNGPYVQ TAGKWGGNVT PGFEERFGAA YDVEVQAWVD AALRGEIGGP
     TAWDGYATAA CCEAGVEAQK SGEKVKVQLN TKPDLYK