IOLG1_SACEN
ID IOLG1_SACEN Reviewed; 337 AA.
AC A4FDY3;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Inositol 2-dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_01671};
DE EC=1.1.1.18 {ECO:0000255|HAMAP-Rule:MF_01671};
DE AltName: Full=Myo-inositol 2-dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_01671};
DE Short=MI 2-dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_01671};
GN Name=iolG1 {ECO:0000255|HAMAP-Rule:MF_01671}; OrderedLocusNames=SACE_2980;
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC Saccharopolyspora.
OX NCBI_TaxID=405948;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC 2338;
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
CC -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-
CC inositol (2KMI or 2-inosose). {ECO:0000255|HAMAP-Rule:MF_01671}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose;
CC Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268,
CC ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01671};
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01671}.
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000255|HAMAP-
CC Rule:MF_01671}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM02258.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AM420293; CAM02258.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_029621968.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FDY3; -.
DR SMR; A4FDY3; -.
DR STRING; 405948.SACE_2980; -.
DR PRIDE; A4FDY3; -.
DR EnsemblBacteria; CAM02258; CAM02258; SACE_2980.
DR KEGG; sen:SACE_2980; -.
DR eggNOG; COG0673; Bacteria.
DR HOGENOM; CLU_023194_0_1_11; -.
DR OrthoDB; 1465613at2; -.
DR Proteomes; UP000006728; Chromosome.
DR GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01671; IolG; 1.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR023794; MI/DCI_dehydrogenase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1..337
FT /note="Inositol 2-dehydrogenase 1"
FT /id="PRO_0000352590"
SQ SEQUENCE 337 AA; 35446 MW; 0C12AEBE8A6A7B95 CRC64;
MTVRVGVVGT GVMGADHVRT LTGGVAGARV VAVSDADQGR GRAVAAEAGD EVVFHADPVD
LIGDAGVDAV VVASPDHTHE ALATACVEAG KPVLCEKPLA ATAADCLRIV AHEVAKGRRL
VQAGYMRRFD PSYVDMKRAL DAGSIGDPVL VHCVHRNARA LHFFTPEMPF TSAAVHEFDV
VRWLLSSEIV RVTVHRTRSS SRAAARLADP RLLVLETAAG VTVDVEVFVN AQYGYDVRCE
LVGELGTVSL ALPSTTVVRA GGAEGVAVHA DFRTRFAEAY RLQLQAWVDA AARGEACGPS
AWDGYAATAV AEACLRAQED GTPVEVELAD KPALYGT