ID   IOLG2_PAEAT             Reviewed;         332 AA.
AC   A1R674;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Inositol 2-dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_01671};
DE            EC=1.1.1.18 {ECO:0000255|HAMAP-Rule:MF_01671};
DE   AltName: Full=Myo-inositol 2-dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_01671};
DE            Short=MI 2-dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_01671};
GN   Name=iolG2 {ECO:0000255|HAMAP-Rule:MF_01671}; OrderedLocusNames=AAur_1991;
OS   Paenarthrobacter aurescens (strain TC1).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Paenarthrobacter.
OX   NCBI_TaxID=290340;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TC1;
RX   PubMed=17194220; DOI=10.1371/journal.pgen.0020214;
RA   Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B.,
RA   Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V.,
RA   Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.;
RT   "Secrets of soil survival revealed by the genome sequence of Arthrobacter
RT   aurescens TC1.";
RL   PLoS Genet. 2:2094-2106(2006).
CC   -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-
CC       inositol (2KMI or 2-inosose). {ECO:0000255|HAMAP-Rule:MF_01671}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose;
CC         Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268,
CC         ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01671};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01671}.
CC   -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01671}.
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DR   EMBL; CP000474; ABM08382.1; -; Genomic_DNA.
DR   RefSeq; WP_011774680.1; NC_008711.1.
DR   AlphaFoldDB; A1R674; -.
DR   SMR; A1R674; -.
DR   STRING; 290340.AAur_1991; -.
DR   EnsemblBacteria; ABM08382; ABM08382; AAur_1991.
DR   KEGG; aau:AAur_1991; -.
DR   eggNOG; COG0673; Bacteria.
DR   HOGENOM; CLU_023194_0_1_11; -.
DR   OMA; CGAQAHT; -.
DR   OrthoDB; 1465613at2; -.
DR   Proteomes; UP000000637; Chromosome.
DR   GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01671; IolG; 1.
DR   InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR   InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR   InterPro; IPR023794; MI/DCI_dehydrogenase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..332
FT                   /note="Inositol 2-dehydrogenase 2"
FT                   /id="PRO_0000352552"
SQ   SEQUENCE   332 AA;  34727 MW;  D86D3F17C1AF5CB7 CRC64;
     MPIRVGVIGA GVMGADHIRN LSTTIGGAKV TFVADLDAGR AAAAAPPSAR ITTDPTELIN
     SSDVDAVVVA SHDSTHAGLV LECFEAMTPV LCEKPLAPTL LESLEVVAAD ADIVAATGAS
     LLSLGFMRRF DPGYVALRQA VQGRVQGEPL MVHCVSRNAA AGPGTTSELA ITNSAIHELD
     IIPWLLGSPV TEVSWQAGKQ TSRAEPGLQD PSFMTLRTAD GTLTTLELYL NAQYGYTTRC
     EVVSEQGTTS LQESSLLGIE QDGTRQAVIP ADWRPRFADA YRLQLQAWIS ALAGGEAPSL
     AGAQDGLNAS LVAQAMIQSL HSDGTTTKVS YS