ID   IOLG4_SACEN             Reviewed;         338 AA.
AC   A4FK61;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Inositol 2-dehydrogenase 4 {ECO:0000255|HAMAP-Rule:MF_01671};
DE            EC=1.1.1.18 {ECO:0000255|HAMAP-Rule:MF_01671};
DE   AltName: Full=Myo-inositol 2-dehydrogenase 4 {ECO:0000255|HAMAP-Rule:MF_01671};
DE            Short=MI 2-dehydrogenase 4 {ECO:0000255|HAMAP-Rule:MF_01671};
GN   Name=iolG4 {ECO:0000255|HAMAP-Rule:MF_01671}; OrderedLocusNames=SACE_5193;
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338;
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-
CC       inositol (2KMI or 2-inosose). {ECO:0000255|HAMAP-Rule:MF_01671}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose;
CC         Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268,
CC         ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01671};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01671}.
CC   -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01671}.
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DR   EMBL; AM420293; CAM04436.1; -; Genomic_DNA.
DR   RefSeq; WP_009942423.1; NZ_PDBV01000001.1.
DR   AlphaFoldDB; A4FK61; -.
DR   SMR; A4FK61; -.
DR   STRING; 405948.SACE_5193; -.
DR   EnsemblBacteria; CAM04436; CAM04436; SACE_5193.
DR   KEGG; sen:SACE_5193; -.
DR   eggNOG; COG0673; Bacteria.
DR   HOGENOM; CLU_023194_0_1_11; -.
DR   OMA; VNCKYGY; -.
DR   OrthoDB; 1465613at2; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01671; IolG; 1.
DR   InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR   InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR   InterPro; IPR023794; MI/DCI_dehydrogenase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..338
FT                   /note="Inositol 2-dehydrogenase 4"
FT                   /id="PRO_0000352593"
SQ   SEQUENCE   338 AA;  35762 MW;  EBBBCF4D8DE2D9CC CRC64;
     MSNRELRVGL VGAGLMGSDH ATRIHRRISG ASLVAVGDPD LERAERAAAG IEGCQVETDP
     LKVIEASDVD AVVLATPGRT HEPLLLAAIE RGIPVLCEKP LTPDSKSSLR VVEAEVAAGR
     RLVQVGFMRR FDPEYAELKR TLHAGALGRP LLMHCAHRNA SAPPGFTSQM MIFDSVVHEF
     DTTRWLLGEE ITAVSVRHPR STANAPSGMT DPQLVTIETA SGVLVTVEIF VNCGFGYQVR
     CEAVCEGGTA QVGGDSGMTT HVRGAWGGSV APDFRPRFQQ AFDEELQRWA DAARAGGIDG
     ASAWDGCAAA AACEAGVAAQ TSGARTPVQL VERPGLYA