IOLG_ACIC1
ID IOLG_ACIC1 Reviewed; 341 AA.
AC A0LVX1;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Inositol 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
DE EC=1.1.1.18 {ECO:0000255|HAMAP-Rule:MF_01671};
DE AltName: Full=Myo-inositol 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
DE Short=MI 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
GN Name=iolG {ECO:0000255|HAMAP-Rule:MF_01671}; OrderedLocusNames=Acel_1809;
OS Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B).
OC Bacteria; Actinobacteria; Acidothermales; Acidothermaceae; Acidothermus.
OX NCBI_TaxID=351607;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43068 / DSM 8971 / 11B;
RX PubMed=19270083; DOI=10.1101/gr.084848.108;
RA Barabote R.D., Xie G., Leu D.H., Normand P., Necsulea A., Daubin V.,
RA Medigue C., Adney W.S., Xu X.C., Lapidus A., Parales R.E., Detter C.,
RA Pujic P., Bruce D., Lavire C., Challacombe J.F., Brettin T.S., Berry A.M.;
RT "Complete genome of the cellulolytic thermophile Acidothermus
RT cellulolyticus 11B provides insights into its ecophysiological and
RT evolutionary adaptations.";
RL Genome Res. 19:1033-1043(2009).
CC -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-
CC inositol (2KMI or 2-inosose). {ECO:0000255|HAMAP-Rule:MF_01671}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose;
CC Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268,
CC ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01671};
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01671}.
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000255|HAMAP-
CC Rule:MF_01671}.
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DR EMBL; CP000481; ABK53581.1; -; Genomic_DNA.
DR RefSeq; WP_011720644.1; NC_008578.1.
DR AlphaFoldDB; A0LVX1; -.
DR SMR; A0LVX1; -.
DR STRING; 351607.Acel_1809; -.
DR EnsemblBacteria; ABK53581; ABK53581; Acel_1809.
DR KEGG; ace:Acel_1809; -.
DR eggNOG; COG0673; Bacteria.
DR HOGENOM; CLU_023194_0_1_11; -.
DR OMA; FRDHPCP; -.
DR OrthoDB; 1465613at2; -.
DR Proteomes; UP000008221; Chromosome.
DR GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01671; IolG; 1.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR023794; MI/DCI_dehydrogenase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1..341
FT /note="Inositol 2-dehydrogenase"
FT /id="PRO_0000352549"
SQ SEQUENCE 341 AA; 36761 MW; 9B5142D9C73CA3E1 CRC64;
MATDRSVRIG LIGAGAIGED HARRLSTVIR GADVVAVHDV DPSRAKTVAT RFRDARVIPD
GNSLIGDPDV DAVVVASAAP THEAYVLAAI AARKPVFCEK PLATTAAGCL RIVEAEKAHG
RRFVRVGFMR RFDPAYLGLK AELRSGAIGH PLLAHLAHRN PAVPSTLRTT DAIADSLVHE
MDLVRWLFDT EIREVRAVAG RRNAKAGPDL HDPLLVLVRM ATDVVVDVEL SLNIGYGYHI
RAEIVGENGT VALASEQPIV RRISGEERRP VAQHWKTRFA AAYDAELSEW VRDVSQGRVS
GPSAWDGYAA TLATDAAAES LRSDTAVAAF PGDVPTLYRE P