IOLG_BURA4
ID IOLG_BURA4 Reviewed; 337 AA.
AC B1YNW1;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Inositol 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
DE EC=1.1.1.18 {ECO:0000255|HAMAP-Rule:MF_01671};
DE AltName: Full=Myo-inositol 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
DE Short=MI 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
GN Name=iolG {ECO:0000255|HAMAP-Rule:MF_01671};
GN OrderedLocusNames=BamMC406_1347;
OS Burkholderia ambifaria (strain MC40-6).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=398577;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC40-6;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Ramette A.,
RA Konstantinidis K., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-
CC inositol (2KMI or 2-inosose). {ECO:0000255|HAMAP-Rule:MF_01671}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose;
CC Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268,
CC ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01671};
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01671}.
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000255|HAMAP-
CC Rule:MF_01671}.
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DR EMBL; CP001025; ACB63835.1; -; Genomic_DNA.
DR RefSeq; WP_012363689.1; NC_010551.1.
DR AlphaFoldDB; B1YNW1; -.
DR SMR; B1YNW1; -.
DR EnsemblBacteria; ACB63835; ACB63835; BamMC406_1347.
DR KEGG; bac:BamMC406_1347; -.
DR HOGENOM; CLU_023194_0_1_4; -.
DR OMA; VNCKYGY; -.
DR OrthoDB; 1465613at2; -.
DR Proteomes; UP000001680; Chromosome 1.
DR GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01671; IolG; 1.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR023794; MI/DCI_dehydrogenase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW NAD; Oxidoreductase.
FT CHAIN 1..337
FT /note="Inositol 2-dehydrogenase"
FT /id="PRO_0000352559"
SQ SEQUENCE 337 AA; 36527 MW; 4B823BB514C83CF9 CRC64;
MTLQIGVIGC GAIGQDHIRR LTRKLSGARV VAVNDIDPQQ ARDAVTKYGL DAEIYGDGHE
VVAAADVQAV LVTSWGPTHE AFVLDAIAHG KPVFCEKPLA VTAQGCMRIV EAEVAHGRRL
VQVGFMRPYD EGYRALKHVI DSGGIGAPLM LHCAHRNQSV GERYTTDMAI TDTLIHELDV
LRWLLGEDYT SAQVVYPKKT RHASAHLADP QIVLLETASG VRIDVEIFVN CQYGYDIQCE
VVGENGIAKL PDPPAVGLKH AARQSVEIMT DWKERFIASY DVELQAFIDG VRQGALTGPS
AWDGYAAAVA ADACVRAQQS GAVEPIAMAE RPAFYRG