ID   IOLG_CERSK              Reviewed;         334 AA.
AC   B9KTD9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Inositol 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
DE            EC=1.1.1.18 {ECO:0000255|HAMAP-Rule:MF_01671};
DE   AltName: Full=Myo-inositol 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
DE            Short=MI 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
GN   Name=iolG {ECO:0000255|HAMAP-Rule:MF_01671};
GN   OrderedLocusNames=RSKD131_3457;
OS   Cereibacter sphaeroides (strain KD131 / KCTC 12085) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=557760;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KD131 / KCTC 12085;
RX   PubMed=19028901; DOI=10.1128/jb.01565-08;
RA   Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K.;
RT   "Complete genome sequence of Rhodobacter sphaeroides KD131.";
RL   J. Bacteriol. 191:1118-1119(2009).
CC   -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-
CC       inositol (2KMI or 2-inosose). {ECO:0000255|HAMAP-Rule:MF_01671}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose;
CC         Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268,
CC         ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01671};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01671}.
CC   -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01671}.
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DR   EMBL; CP001151; ACM03317.1; -; Genomic_DNA.
DR   RefSeq; WP_012641034.1; NC_011958.1.
DR   AlphaFoldDB; B9KTD9; -.
DR   SMR; B9KTD9; -.
DR   EnsemblBacteria; ACM03317; ACM03317; RSKD131_3457.
DR   GeneID; 67448790; -.
DR   KEGG; rsk:RSKD131_3457; -.
DR   HOGENOM; CLU_023194_0_1_5; -.
DR   OMA; VNCKYGY; -.
DR   Proteomes; UP000001597; Chromosome 2.
DR   GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01671; IolG; 1.
DR   InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR   InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR   InterPro; IPR023794; MI/DCI_dehydrogenase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..334
FT                   /note="Inositol 2-dehydrogenase"
FT                   /id="PRO_1000187320"
SQ   SEQUENCE   334 AA;  36099 MW;  7995F14670D96FF7 CRC64;
     MTLRIGIIGT GAIGTDHARR INRVLSGAEV TAVTDVNRDN AEACVAGVAP GAQILGSAEE
     VIAASDAVLV CSWGAAHEAQ VLAAIAAGKP CFCEKPLATE AYGARRIVEA EEAMGRRLVQ
     VGFMRRYDRG YVALKETVRT RLGPPLMIHA AHRNPTVPGR YRTPMAIHDT LIHEIDVLRW
     LLDDEYVSAQ VIFPRATRHT HAGLRDPQIV LLETAKGVRI DVEIFVNCRY GYDIQCEVVG
     EEGTARLPEP TAIPTRLGAV FGQPILMDWK DRFIDSYDVE LQDFLKAAAQ GTAAGPSAWD
     GYVAAITADV CAQAQERPGA ILPVTLPARP ALYA