IOLG_PSECP
ID IOLG_PSECP Reviewed; 337 AA.
AC B8HDD2;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Inositol 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
DE EC=1.1.1.18 {ECO:0000255|HAMAP-Rule:MF_01671};
DE AltName: Full=Myo-inositol 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
DE Short=MI 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
GN Name=iolG {ECO:0000255|HAMAP-Rule:MF_01671}; OrderedLocusNames=Achl_0942;
OS Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP
OS 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter
OS chlorophenolicus).
OC Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Pseudarthrobacter.
OX NCBI_TaxID=452863;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB
RC 13794 / A6;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.;
RT "Complete sequence of chromosome of Arthrobacter chlorophenolicus A6.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-
CC inositol (2KMI or 2-inosose). {ECO:0000255|HAMAP-Rule:MF_01671}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose;
CC Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268,
CC ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01671};
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01671}.
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000255|HAMAP-
CC Rule:MF_01671}.
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DR EMBL; CP001341; ACL38937.1; -; Genomic_DNA.
DR RefSeq; WP_015936160.1; NC_011886.1.
DR AlphaFoldDB; B8HDD2; -.
DR SMR; B8HDD2; -.
DR STRING; 452863.Achl_0942; -.
DR EnsemblBacteria; ACL38937; ACL38937; Achl_0942.
DR KEGG; ach:Achl_0942; -.
DR eggNOG; COG0673; Bacteria.
DR HOGENOM; CLU_023194_0_1_11; -.
DR OMA; RKPVMCE; -.
DR OrthoDB; 1465613at2; -.
DR Proteomes; UP000002505; Chromosome.
DR GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01671; IolG; 1.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR023794; MI/DCI_dehydrogenase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW NAD; Oxidoreductase.
FT CHAIN 1..337
FT /note="Inositol 2-dehydrogenase"
FT /id="PRO_1000187316"
SQ SEQUENCE 337 AA; 36074 MW; 436281063050F881 CRC64;
MTETLRVAVI GAGRMGADHI QRLHQRIHGA EVAAVVDVDL ARAQAAIEGI PGAVALADAE
EALNNGDVNA VLIATPGFLH EDILLKAIAK DIPILCEKPL TPDAESSLKI VEAEVALGRK
RIQVGFMRRF DAEYAALGSI IRNQELGELL MLHHQHRNPT TPAGFTNEML INDSVVHEFD
AIRFFTGEEI TSVQVRLGKV TKNAPAGQHD PQHVLIETES GVLADVEIYV NAKFGYEVAT
QASFEDGIVS IGGDKGPYTR SAGRWGGNVT PGFEERFGAA YDVEIQSWVD AALRGEIGGP
SAWDGYATAA CCEAGVEAQK NGEKVAVKLA AKPDLYS