ID   IOLG_RHOE4              Reviewed;         346 AA.
AC   C0ZWI9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Inositol 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
DE            EC=1.1.1.18 {ECO:0000255|HAMAP-Rule:MF_01671};
DE   AltName: Full=Myo-inositol 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
DE            Short=MI 2-dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01671};
GN   Name=iolG {ECO:0000255|HAMAP-Rule:MF_01671}; OrderedLocusNames=RER_20160;
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus;
OC   Rhodococcus erythropolis group.
OX   NCBI_TaxID=234621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT   PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-
CC       inositol (2KMI or 2-inosose). {ECO:0000255|HAMAP-Rule:MF_01671}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose;
CC         Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268,
CC         ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01671};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01671}.
CC   -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01671}.
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DR   EMBL; AP008957; BAH32724.1; -; Genomic_DNA.
DR   RefSeq; WP_020906996.1; NC_012490.1.
DR   AlphaFoldDB; C0ZWI9; -.
DR   SMR; C0ZWI9; -.
DR   STRING; 234621.RER_20160; -.
DR   PRIDE; C0ZWI9; -.
DR   EnsemblBacteria; BAH32724; BAH32724; RER_20160.
DR   KEGG; rer:RER_20160; -.
DR   PATRIC; fig|234621.6.peg.2516; -.
DR   eggNOG; COG0673; Bacteria.
DR   HOGENOM; CLU_023194_0_1_11; -.
DR   OMA; VNCKYGY; -.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01671; IolG; 1.
DR   InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR   InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR   InterPro; IPR023794; MI/DCI_dehydrogenase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..346
FT                   /note="Inositol 2-dehydrogenase"
FT                   /id="PRO_1000215886"
SQ   SEQUENCE   346 AA;  36778 MW;  5E412B3190A3377A CRC64;
     MSDNQDLRIA VLGVGIMGAD HVDRITNKIG GARVTVVNDY SLARAEEIAA LTPGSRVVVD
     PFDAIAAEDV DAVVLATPGP THEKQVLACL EAGKPVLCEK PLTTDADSSL AIVKAEAALG
     KKLIQVGFMR RFDHEYTQLK YLIDSGDLGR PLVVHCAHRN PAVPNGFDSA MIVKDSLVHE
     VDVTRFLLDE EITSVQIIRP SANSLAPEGI QDPQIAIFET ESGRHVDAEV FVTTGVAYEV
     RTEVVGELGS AMIGLDVGLI RKTKPGNWGG QITPGFRERF GQAYDTEFAR WIKAVKTGAG
     TGNYIDGPGA WDGYAAAAVC AAGVKSLETG QRVVVDMVAR DSVAGA