ID   ION3_CARAU              Reviewed;         520 AA.
AC   P18520;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Intermediate filament protein ON3;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Glial cell;
RX   PubMed=2483326; DOI=10.1016/0896-6273(89)90197-9;
RA   Giordano S., Glasgow E., Tesser P., Schechter N.;
RT   "A type II keratin is expressed in glial cells of the goldfish visual
RT   pathway.";
RL   Neuron 2:1507-1516(1989).
CC   -!- FUNCTION: One of the non-neuronal predominant intermediate filament
CC       proteins of the visual pathway.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; M87773; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; JS0291; JS0291.
DR   AlphaFoldDB; P18520; -.
DR   SMR; P18520; -.
DR   PRIDE; P18520; -.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Reference proteome;
KW   Sensory transduction; Vision.
FT   CHAIN           1..520
FT                   /note="Intermediate filament protein ON3"
FT                   /id="PRO_0000063750"
FT   DOMAIN          109..420
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..108
FT                   /note="Head"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..144
FT                   /note="Coil 1A"
FT   REGION          145..157
FT                   /note="Linker 1"
FT   REGION          158..253
FT                   /note="Coil 1B"
FT   REGION          254..273
FT                   /note="Linker 12"
FT   REGION          274..420
FT                   /note="Coil 2"
FT   REGION          421..520
FT                   /note="Tail"
SQ   SEQUENCE   520 AA;  57789 MW;  84678B07F8A5CF57 CRC64;
     MSYTKKTSYS VKSSSSGSVP RSFSSMSYSG PSVTRQSYSV RTSYGGANRG MGAGMGGGGF
     ISSSSAYGLG MGMGSGVVAP IQAVTFNKSL LAPLNLEIDP NIQVVRTQEK EQMKSLNNRF
     ASFIDKVRFL EQQNKMLETK WSLLQNQTAT RSNIDAMFEA YINNLRRQLD SLGNDKMKLE
     ADLHNMQGLV EDFKNKYEDE INKRTECEND FVLIKKDVDE AYMNKVELEA KLESLSDEIN
     FLRQIFEEEI RELQSQIKDT SVVVEMDNSR NLDMDAIVAE VRAQYEDIAN RSRAEAEMWY
     KSKYEEMQTS ATKYGDDLRS TKTEIADLNR MIQRLQSEID AVKGQRSNLE NQIAEAEERG
     ELAVRDAKAR IKDLEDALQR AKQDMARQIR EYQELMNVKL ALDIEIATYR KLLEGEEDRL
     LSGIKSVNIS KQSTSYGSYP MESASSGYSN YSSGYGGGYG GGYSSGGGYS SGGGYSSGGG
     YSSGSGYSET VSQTKKSVVI KMIETKDGRV VSESSEVVQD