IORB_METTM
ID IORB_METTM Reviewed; 196 AA.
AC P80911; D9PUX7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Indolepyruvate oxidoreductase subunit IorB;
DE Short=IOR;
DE EC=1.2.7.8;
DE AltName: Full=Indolepyruvate ferredoxin oxidoreductase subunit beta;
GN Name=iorB; OrderedLocusNames=MTBMA_c04230;
OS Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM
OS 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium
OS thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=79929;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC Marburg;
RX PubMed=20802048; DOI=10.1128/jb.00844-10;
RA Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H.,
RA Gottschalk G., Thauer R.K.;
RT "Complete genome sequence of Methanothermobacter marburgensis, a
RT methanoarchaeon model organism.";
RL J. Bacteriol. 192:5850-5851(2010).
RN [2]
RP PROTEIN SEQUENCE OF 2-29, BIOPHYSICOCHEMICAL PROPERTIES, AND SUBUNIT.
RC STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC Marburg;
RX PubMed=9108258; DOI=10.1111/j.1432-1033.1997.00862.x;
RA Tersteegen A., Linder D., Thauer R.K., Hedderich R.;
RT "Structures and functions of four anabolic 2-oxoacid oxidoreductases in
RT Methanobacterium thermoautotrophicum.";
RL Eur. J. Biochem. 244:862-868(1997).
CC -!- FUNCTION: Catalyzes the ferredoxin-dependent oxidative decarboxylation
CC of arylpyruvates.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] =
CC (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-
CC [ferredoxin]; Xref=Rhea:RHEA:12645, Rhea:RHEA-COMP:10000, Rhea:RHEA-
CC COMP:10001, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17640,
CC ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57271,
CC ChEBI:CHEBI:57287; EC=1.2.7.8;
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC pH dependence:
CC Optimum pH is 10.0. {ECO:0000269|PubMed:9108258};
CC Temperature dependence:
CC Optimum temperature is 80 degrees Celsius.
CC {ECO:0000269|PubMed:9108258};
CC -!- SUBUNIT: Heterodimer of the IorA and IorB subunits.
CC {ECO:0000269|PubMed:9108258}.
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DR EMBL; CP001710; ADL58024.1; -; Genomic_DNA.
DR RefSeq; WP_013295250.1; NC_014408.1.
DR AlphaFoldDB; P80911; -.
DR SMR; P80911; -.
DR STRING; 79929.MTBMA_c04230; -.
DR EnsemblBacteria; ADL58024; ADL58024; MTBMA_c04230.
DR GeneID; 9704129; -.
DR KEGG; mmg:MTBMA_c04230; -.
DR PATRIC; fig|79929.8.peg.412; -.
DR HOGENOM; CLU_087284_1_1_2; -.
DR OMA; HGMSQRF; -.
DR OrthoDB; 120779at2157; -.
DR Proteomes; UP000000345; Chromosome.
DR GO; GO:0043805; F:indolepyruvate ferredoxin oxidoreductase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.920.10; -; 1.
DR InterPro; IPR017719; Indolepyruvate_Fd_OxRdtase_bsu.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR Pfam; PF01558; POR; 1.
DR SUPFAM; SSF53323; SSF53323; 1.
DR TIGRFAMs; TIGR03334; IOR_beta; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Oxidoreductase.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:9108258"
FT CHAIN 2..196
FT /note="Indolepyruvate oxidoreductase subunit IorB"
FT /id="PRO_0000099933"
SQ SEQUENCE 196 AA; 21068 MW; 35887D4852C8643C CRC64;
MSYNIYVCGV GGQGIIKTSV IIGEAAMNEG MNVVMSEIHG MAQRGGAVST EIRFGDVRGS
IIPQGEADLV IAFEPLEALR ALPKMSEDAC VIVNTSKIPP FNLIKSPHPY PPLEEIIKTL
EENAGRVRSF NGEKIAVEAG HILSLNMVML GAAAATTGFP LGEETLIESM KNNLPPKLME
VNLRAFHEGF ETVNCD
