ID   IORF_CVHN1              Reviewed;         205 AA.
AC   Q5MQC5;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   29-SEP-2021, entry version 55.
DE   RecName: Full=Protein I;
DE   AltName: Full=Accessory protein N2;
DE   AltName: Full=N internal ORF protein;
DE            Short=IORF;
DE   AltName: Full=Orf8 protein;
DE   AltName: Full=Protein in nucleocapsid ORF;
GN   Name=N; Synonyms=I; ORFNames=7b;
OS   Human coronavirus HKU1 (isolate N1) (HCoV-HKU1).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Embecovirus.
OX   NCBI_TaxID=443239;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15613317; DOI=10.1128/jvi.79.2.884-895.2005;
RA   Woo P.C.Y., Lau S.K.P., Chu C.-M., Chan K.-H., Tsoi H.-W., Huang Y.,
RA   Wong B.H.L., Poon R.W.S., Cai J.J., Luk W.-K., Poon L.L.M., Wong S.S.Y.,
RA   Guan Y., Peiris J.S.M., Yuen K.-Y.;
RT   "Characterization and complete genome sequence of a novel coronavirus,
RT   coronavirus HKU1, from patients with pneumonia.";
RL   J. Virol. 79:884-895(2005).
CC   -!- FUNCTION: Structural protein that is not essential for the viral
CC       replication either in tissue culture or in its natural host.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}.
CC   -!- MISCELLANEOUS: The gene encoding this protein is included within the N
CC       gene (alternative ORF).
CC   -!- MISCELLANEOUS: Isolate N1 belongs to genotype A.
CC   -!- SIMILARITY: Belongs to the coronavirus I protein family. {ECO:0000305}.
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DR   EMBL; AY597011; AAT98586.1; -; Genomic_RNA.
DR   RefSeq; YP_173243.1; NC_006577.2.
DR   DNASU; 3200424; -.
DR   GeneID; 3200424; -.
DR   KEGG; vg:3200424; -.
DR   Proteomes; UP000008170; Genome.
DR   CDD; cd21662; embe-CoV_Protein-I_like; 1.
DR   InterPro; IPR004876; Corona_nucI.
DR   InterPro; IPR044311; N2-like_embe-CoV.
DR   Pfam; PF03187; Corona_I; 1.
PE   3: Inferred from homology;
KW   Virion.
FT   CHAIN           1..205
FT                   /note="Protein I"
FT                   /id="PRO_0000297764"
SQ   SEQUENCE   205 AA;  22794 MW;  3BF727484CA2235D CRC64;
     MLEVEAPLEI VQESSRKLLG LTNLSEITKP LIEAEKPNLN SLCLLNHKEI LSHIIPGSPG
     SLNFKKVETL NFQMVKEFPL LSEYPLLKQK DIGIDTAGVL LKQLMVNKSS CYRDGISTIS
     VPAHMPMHPM VNPSKGSSGL LITKLTLLLP PMFRQGILLL KKLSLLGFRL VRFCLKAIML
     KAQEGLLLIV DQVHVLNHVD PIIVH