ID   IORF_CVHN2              Reviewed;         205 AA.
AC   P0C5B5;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   29-SEP-2021, entry version 26.
DE   RecName: Full=Protein I;
DE   AltName: Full=Accessory protein N2;
DE   AltName: Full=N internal ORF protein;
DE            Short=IORF;
DE   AltName: Full=Orf8 protein;
DE   AltName: Full=Protein in nucleocapsid ORF;
GN   Name=N; Synonyms=I; ORFNames=7b;
OS   Human coronavirus HKU1 (isolate N2) (HCoV-HKU1).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Embecovirus.
OX   NCBI_TaxID=443240;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16809319; DOI=10.1128/jvi.00509-06;
RA   Woo P.C.Y., Lau S.K.P., Yip C.C.Y., Huang Y., Tsoi H.-W., Chan K.-H.,
RA   Yuen K.-Y.;
RT   "Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel
RT   genotype and evidence of natural recombination in coronavirus HKU1.";
RL   J. Virol. 80:7136-7145(2006).
CC   -!- FUNCTION: Structural protein that is not essential for the viral
CC       replication either in tissue culture or in its natural host.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}.
CC   -!- MISCELLANEOUS: The gene encoding this protein is included within the N
CC       gene (alternative ORF).
CC   -!- MISCELLANEOUS: Isolate N2 belongs to genotype B.
CC   -!- SIMILARITY: Belongs to the coronavirus I protein family. {ECO:0000305}.
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DR   EMBL; AY884001; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   Proteomes; UP000006551; Genome.
DR   CDD; cd21662; embe-CoV_Protein-I_like; 1.
DR   InterPro; IPR004876; Corona_nucI.
DR   InterPro; IPR044311; N2-like_embe-CoV.
DR   Pfam; PF03187; Corona_I; 1.
PE   3: Inferred from homology;
KW   Virion.
FT   CHAIN           1..205
FT                   /note="Protein I"
FT                   /id="PRO_0000297765"
SQ   SEQUENCE   205 AA;  22718 MW;  40FFC07B01DC7B52 CRC64;
     MLEVEAPLEI VQESSRKLLG LTNLSEAIKP IIEAENPNPN SLCLLNHKET LSHIIPGSLG
     LPNFKKVETL NFQMVKEYPL LTGYPLLKQK DIGINTTGVL LKQLMVNKSS CYQDGISTIS
     VPVHMPVHPM VMPTKVSSGS LVTKLTLLFP PMFRQGILLF KKLSLLGFRL VRFCLKAIML
     KAQEGLLLIA GQVHVLNHVD PIIVH