ID   IORF_CVHOC              Reviewed;         207 AA.
AC   Q4VID0; Q6TNF4;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Protein I;
DE   AltName: Full=Accessory protein N2;
DE   AltName: Full=N internal ORF protein;
DE            Short=IORF;
DE   AltName: Full=Protein in nucleocapsid ORF;
GN   Name=N; Synonyms=I; ORFNames=7b;
OS   Human coronavirus OC43 (HCoV-OC43).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Embecovirus.
OX   NCBI_TaxID=31631;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate 19572 Belgium 2004;
RX   PubMed=15914223; DOI=10.1016/j.virol.2005.04.010;
RA   Vijgen L., Keyaerts E., Lemey P., Moes E., Li S., Vandamme A.M.,
RA   Van Ranst M.;
RT   "Circulation of genetically distinct contemporary human coronavirus OC43
RT   strains.";
RL   Virology 337:85-92(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate ATCC VR-759, and Isolate clinical OC43-Paris;
RX   PubMed=15280490; DOI=10.1128/jvi.78.16.8824-8834.2004;
RA   St Jean J.R., Jacomy H., Desforges M., Vabret A., Freymuth F., Talbot P.J.;
RT   "Human respiratory coronavirus OC43: genetic stability and neuroinvasion.";
RL   J. Virol. 78:8824-8834(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate ATCC VR-759;
RX   PubMed=15650185; DOI=10.1128/jvi.79.3.1595-1604.2005;
RA   Vijgen L., Keyaerts E., Moes E., Thoelen I., Wollants E., Lemey P.,
RA   Vandamme A.M., Van Ranst M.;
RT   "Complete genomic sequence of human coronavirus OC43: molecular clock
RT   analysis suggests a relatively recent zoonotic coronavirus transmission
RT   event.";
RL   J. Virol. 79:1595-1604(2005).
CC   -!- FUNCTION: Structural protein that is not essential for the viral
CC       replication either in tissue culture or in its natural host.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}.
CC   -!- MISCELLANEOUS: The gene encoding this protein is included within the N
CC       gene (alternative ORF).
CC   -!- SIMILARITY: Belongs to the coronavirus I protein family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY903460; AAX85683.1; -; Genomic_RNA.
DR   EMBL; AY585228; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; AY585229; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; AY391777; AAR01020.1; ALT_SEQ; Genomic_RNA.
DR   Proteomes; UP000007552; Genome.
DR   Proteomes; UP000100580; Genome.
DR   Proteomes; UP000159995; Genome.
DR   Proteomes; UP000180344; Genome.
DR   CDD; cd21662; embe-CoV_Protein-I_like; 1.
DR   InterPro; IPR004876; Corona_nucI.
DR   InterPro; IPR044311; N2-like_embe-CoV.
DR   Pfam; PF03187; Corona_I; 1.
PE   3: Inferred from homology;
KW   Virion.
FT   CHAIN           1..207
FT                   /note="Protein I"
FT                   /id="PRO_0000284099"
FT   VARIANT         1..92
FT                   /note="Missing (in strain: Isolate ATCC VR-759)"
FT   VARIANT         30
FT                   /note="L -> P (in strain: Isolate clinical OC43-Paris)"
FT   VARIANT         194
FT                   /note="A -> V (in strain: Isolate ATCC VR-759 and Isolate
FT                   clinical OC43-Paris)"
FT   VARIANT         204
FT                   /note="P -> L (in strain: Isolate ATCC VR-759 and Isolate
FT                   clinical OC43-Paris)"
SQ   SEQUENCE   207 AA;  22895 MW;  93F17A9D17364769 CRC64;
     MASSSGPISP TSLEMFKPGV EELNPSKLLL LSNHQEGMLY PTILGSLELL SFKRERSLSL
     QKDKVCLLHQ ESQLLKLRGT GTDTTDVLLK QPMATSVNCC HDGIFTIWEQ DRMLKTSTAP
     ILTESTGSLA TRLMSIPRLT LSIGTQVAMR LFRLGFRLAR YSLRVTILKA QEGLLLIPDL
     LRAHPAEPLV QDRAVEPILA IEPPPLV