ID   IOTA_GONVI              Reviewed;          63 AA.
AC   P82025;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   11-DEC-2019, entry version 68.
DE   RecName: Full=Iota-crystallin;
DE   Flags: Fragment;
GN   Name=CRBPI;
OS   Gonatodes vittatus (Wiegmann's striped gecko) (Gymnodactylus vittatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Gekkota; Sphaerodactylidae; Gonatodes.
OX   NCBI_TaxID=104610;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-63, AND FUNCTION.
RC   TISSUE=Lens;
RX   PubMed=10725366; DOI=10.1073/pnas.97.7.3282;
RA   Werten P.J.L., Roell B., van Aalten D.M.F., de Jong W.W.;
RT   "Gecko iota-crystallin: how cellular retinol-binding protein became an eye
RT   lens ultraviolet filter.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:3282-3287(2000).
CC   -!- FUNCTION: Binds vitamin A2 in the eye lens and thus functions as a UV
CC       filter. Intracellular transport of retinol.
CC       {ECO:0000269|PubMed:10725366}.
CC   -!- DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic
CC       ligands in its interior. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC       protein (FABP) family. {ECO:0000305}.
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DR   PRIDE; P82025; -.
DR   GO; GO:0016918; F:retinal binding; IEA:UniProtKB-KW.
DR   GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR031270; CRBP-III.
DR   InterPro; IPR031259; ILBP.
DR   PANTHER; PTHR11955; PTHR11955; 1.
DR   PANTHER; PTHR11955:SF74; PTHR11955:SF74; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Retinol-binding; Transport; Vitamin A.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:10725366"
FT   CHAIN           2..>63
FT                   /note="Iota-crystallin"
FT                   /id="PRO_0000067402"
FT   NON_TER         63
SQ   SEQUENCE   63 AA;  7495 MW;  205279E1BA2D4DC5 CRC64;
     MPPNLTGYWR FVSQDNMDNY LRALDLNVAL RKLVXLLKFD KEIVHEGNHM TIRTLXTXRN
     YXI