IOVO_ANTVI
ID IOVO_ANTVI Reviewed; 54 AA.
AC P68381; P05612;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Ovomucoid;
DE Flags: Fragment;
OS Anthropoides virgo (Demoiselle crane) (Grus virgo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Grus.
OX NCBI_TaxID=9111;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=3828298; DOI=10.1021/bi00375a028;
RA Laskowski M. Jr., Kato I., Ardelt W., Cook J., Denton A., Empie M.W.,
RA Kohr W.J., Park S.J., Parks K., Schatzley B.L., Schoenberger O.L.,
RA Tashiro M., Vichot G., Whatley H.E., Wieczorek A., Wieczorek M.;
RT "Ovomucoid third domains from 100 avian species: isolation, sequences, and
RT hypervariability of enzyme-inhibitor contact residues.";
RL Biochemistry 26:202-221(1987).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- DOMAIN: Avian ovomucoid consists of three homologous, tandem Kazal
CC family inhibitory domains.
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DR PIR; F31439; F31439.
DR AlphaFoldDB; P68381; -.
DR SMR; P68381; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001239; Prot_inh_Kazal-m.
DR Pfam; PF00050; Kazal_1; 1.
DR PRINTS; PR00290; KAZALINHBTR.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR PROSITE; PS00282; KAZAL_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Protease inhibitor; Repeat; Secreted; Serine protease inhibitor.
FT CHAIN <1..>54
FT /note="Ovomucoid"
FT /id="PRO_0000073062"
FT DOMAIN 4..54
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT SITE 16..17
FT /note="Reactive bond 3"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT DISULFID 6..36
FT DISULFID 14..33
FT DISULFID 22..54
FT NON_TER 1
FT NON_TER 54
SQ SEQUENCE 54 AA; 5837 MW; 16B799E43D4DA52E CRC64;
TATVDCSDYP KPACTLEYMP FCGSDSKTYS NKCNFCNAVV DSNGTLTLSH FGKC