ID   IOVO_COLVI              Reviewed;          56 AA.
AC   P05591;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Ovomucoid;
DE   Flags: Fragment;
OS   Colinus virginianus (Northern bobwhite) (Tetrao virginianus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC   Colinus.
OX   NCBI_TaxID=9014;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3828298; DOI=10.1021/bi00375a028;
RA   Laskowski M. Jr., Kato I., Ardelt W., Cook J., Denton A., Empie M.W.,
RA   Kohr W.J., Park S.J., Parks K., Schatzley B.L., Schoenberger O.L.,
RA   Tashiro M., Vichot G., Whatley H.E., Wieczorek A., Wieczorek M.;
RT   "Ovomucoid third domains from 100 avian species: isolation, sequences, and
RT   hypervariability of enzyme-inhibitor contact residues.";
RL   Biochemistry 26:202-221(1987).
RN   [2]
RP   PROTEIN SEQUENCE.
RA   Kato I., Kohr W.J., Laskowski M. Jr.;
RT   "Evolution of avian ovomucoids.";
RL   (In) Magnusson S., Ottesen M., Foltmann B., Dano K., Neurath H. (eds.);
RL   Regulatory proteolytic enzymes and their inhibitors, pp.197-206, Pergamon
RL   Press, New York (1978).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DOMAIN: Avian ovomucoid consists of three homologous, tandem Kazal
CC       family inhibitory domains.
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DR   PIR; C31446; C31446.
DR   AlphaFoldDB; P05591; -.
DR   BMRB; P05591; -.
DR   SMR; P05591; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR001239; Prot_inh_Kazal-m.
DR   Pfam; PF00050; Kazal_1; 1.
DR   PRINTS; PR00290; KAZALINHBTR.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Protease inhibitor; Repeat; Secreted; Serine protease inhibitor.
FT   CHAIN           <1..>56
FT                   /note="Ovomucoid"
FT                   /id="PRO_0000073088"
FT   DOMAIN          6..56
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            18..19
FT                   /note="Reactive bond 3"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   DISULFID        8..38
FT   DISULFID        16..35
FT   DISULFID        24..56
FT   NON_TER         1
FT   NON_TER         56
SQ   SEQUENCE   56 AA;  6101 MW;  617E58543081DC46 CRC64;
     FAAVSVDCSE YPKPACMSEY RPLCGSDNKT YVNKCNFCNA VVESNGTLTL SHFGKC