ID   IOVO_COTDE              Reviewed;          52 AA.
AC   P05600;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Ovomucoid;
DE   Flags: Fragment;
OS   Coturnix delegorguei (Harlequin quail).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=9093;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3828298; DOI=10.1021/bi00375a028;
RA   Laskowski M. Jr., Kato I., Ardelt W., Cook J., Denton A., Empie M.W.,
RA   Kohr W.J., Park S.J., Parks K., Schatzley B.L., Schoenberger O.L.,
RA   Tashiro M., Vichot G., Whatley H.E., Wieczorek A., Wieczorek M.;
RT   "Ovomucoid third domains from 100 avian species: isolation, sequences, and
RT   hypervariability of enzyme-inhibitor contact residues.";
RL   Biochemistry 26:202-221(1987).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DOMAIN: Avian ovomucoid consists of three homologous, tandem Kazal
CC       family inhibitory domains.
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DR   PIR; I31441; I31441.
DR   AlphaFoldDB; P05600; -.
DR   SMR; P05600; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR001239; Prot_inh_Kazal-m.
DR   Pfam; PF00050; Kazal_1; 1.
DR   PRINTS; PR00290; KAZALINHBTR.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Protease inhibitor; Repeat; Secreted; Serine protease inhibitor.
FT   CHAIN           <1..>52
FT                   /note="Ovomucoid"
FT                   /id="PRO_0000073086"
FT   DOMAIN          2..52
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            14..15
FT                   /note="Reactive bond 3"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   DISULFID        4..34
FT   DISULFID        12..31
FT   DISULFID        20..52
FT   NON_TER         1
FT   NON_TER         52
SQ   SEQUENCE   52 AA;  5695 MW;  06AB5859AC4C2612 CRC64;
     SVDCSEYPKP ACPKDYRPVC GSDNKTYGNK CNFCNAVVES NGTLTLNRFG KC