IOVO_DENAU
ID IOVO_DENAU Reviewed; 54 AA.
AC P67891; P05568;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 49.
DE RecName: Full=Ovomucoid;
DE Flags: Fragment;
OS Dendrocygna autumnalis (Black-bellied whistling-duck) (Anas autumnalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Dendrocygninae; Dendrocygna.
OX NCBI_TaxID=8873;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=3828298; DOI=10.1021/bi00375a028;
RA Laskowski M. Jr., Kato I., Ardelt W., Cook J., Denton A., Empie M.W.,
RA Kohr W.J., Park S.J., Parks K., Schatzley B.L., Schoenberger O.L.,
RA Tashiro M., Vichot G., Whatley H.E., Wieczorek A., Wieczorek M.;
RT "Ovomucoid third domains from 100 avian species: isolation, sequences, and
RT hypervariability of enzyme-inhibitor contact residues.";
RL Biochemistry 26:202-221(1987).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- DOMAIN: Avian ovomucoid consists of three homologous, tandem Kazal
CC family inhibitory domains.
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DR PIR; I31436; I31436.
DR AlphaFoldDB; P67891; -.
DR SMR; P67891; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001239; Prot_inh_Kazal-m.
DR Pfam; PF00050; Kazal_1; 1.
DR PRINTS; PR00290; KAZALINHBTR.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR PROSITE; PS00282; KAZAL_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Protease inhibitor; Repeat; Secreted; Serine protease inhibitor.
FT CHAIN <1..>54
FT /note="Ovomucoid"
FT /id="PRO_0000073102"
FT DOMAIN 4..54
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT SITE 16..17
FT /note="Reactive bond 3"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT DISULFID 6..36
FT DISULFID 14..33
FT DISULFID 22..54
FT NON_TER 1
FT NON_TER 54
SQ SEQUENCE 54 AA; 5798 MW; A1FAC304C19FE598 CRC64;
VATVDCSDYP KPACTLEYMP LCGSDNKTYG NKCNFCNAVV DSNGTLTLSH FGKC