ID   IOVO_DRONO              Reviewed;         207 AA.
AC   P05560; B5UBC5;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 3.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Ovomucoid;
DE            Short=OVM;
DE   Flags: Precursor;
OS   Dromaius novaehollandiae (Emu).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Casuariiformes; Dromaiidae; Dromaius.
OX   NCBI_TaxID=8790;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 24-43.
RC   TISSUE=Egg white, and Oviduct;
RX   PubMed=21058653; DOI=10.1021/jf103239v;
RA   Maehashi K., Matano M., Irisawa T., Uchino M., Itagaki Y., Takano K.,
RA   Kashiwagi Y., Watanabe T.;
RT   "Primary structure of potential allergenic proteins in emu (Dromaius
RT   novaehollandiae) egg white.";
RL   J. Agric. Food Chem. 58:12530-12536(2010).
RN   [2]
RP   PROTEIN SEQUENCE OF 154-207.
RX   PubMed=3828298; DOI=10.1021/bi00375a028;
RA   Laskowski M. Jr., Kato I., Ardelt W., Cook J., Denton A., Empie M.W.,
RA   Kohr W.J., Park S.J., Parks K., Schatzley B.L., Schoenberger O.L.,
RA   Tashiro M., Vichot G., Whatley H.E., Wieczorek A., Wieczorek M.;
RT   "Ovomucoid third domains from 100 avian species: isolation, sequences, and
RT   hypervariability of enzyme-inhibitor contact residues.";
RL   Biochemistry 26:202-221(1987).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DOMAIN: Avian ovomucoid consists of three homologous, tandem Kazal
CC       family inhibitory domains.
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DR   EMBL; AB462349; BAG72138.4; -; mRNA.
DR   PIR; A31440; A31440.
DR   AlphaFoldDB; P05560; -.
DR   SMR; P05560; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   Pfam; PF00050; Kazal_1; 3.
DR   SMART; SM00280; KAZAL; 3.
DR   SUPFAM; SSF100895; SSF100895; 3.
DR   PROSITE; PS00282; KAZAL_1; 3.
DR   PROSITE; PS51465; KAZAL_2; 3.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Protease inhibitor; Repeat; Secreted; Serine protease inhibitor; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:21058653"
FT   CHAIN           24..207
FT                   /note="Ovomucoid"
FT                   /id="PRO_0000073106"
FT   DOMAIN          24..87
FT                   /note="Kazal-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DOMAIN          88..152
FT                   /note="Kazal-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DOMAIN          153..207
FT                   /note="Kazal-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            47..48
FT                   /note="Reactive bond 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            112..113
FT                   /note="Reactive bond 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            169..170
FT                   /note="Reactive bond 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        98
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        196
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..67
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        45..64
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        53..85
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        93..132
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        110..129
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        118..150
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        159..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        167..186
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        175..207
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ   SEQUENCE   207 AA;  22295 MW;  5C8204D6B74D8D77 CRC64;
     MTMASVLVLL SLVLCCFPDT AFGVEVDCSK YPNTTNEDGK EVLLCPKILN PICGSDGVTY
     SNDCLLCAYN IEYGANVSKD HDGECKEAVP IDCSKYANAT NEEGKEVPLC TKILSPVCGT
     DGVTYSNECL LCAHNIEQGT SVGKKYDGEC KKEFATVDCS DYPKPVCSLE YMPLCGSDSK
     TYNNKCDFCN AVVESNGTLT LGHFGKC