IOVO_OREPI
ID IOVO_OREPI Reviewed; 56 AA.
AC P05587;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Ovomucoid;
DE Flags: Fragment;
OS Oreortyx pictus (Mountain quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Oreortyx.
OX NCBI_TaxID=9029;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=3828298; DOI=10.1021/bi00375a028;
RA Laskowski M. Jr., Kato I., Ardelt W., Cook J., Denton A., Empie M.W.,
RA Kohr W.J., Park S.J., Parks K., Schatzley B.L., Schoenberger O.L.,
RA Tashiro M., Vichot G., Whatley H.E., Wieczorek A., Wieczorek M.;
RT "Ovomucoid third domains from 100 avian species: isolation, sequences, and
RT hypervariability of enzyme-inhibitor contact residues.";
RL Biochemistry 26:202-221(1987).
RN [2]
RP PROTEIN SEQUENCE.
RX PubMed=7046785; DOI=10.1021/bi00539a002;
RA Empie M.W., Laskowski M. Jr.;
RT "Thermodynamics and kinetics of single residue replacements in avian
RT ovomucoid third domains: effect on inhibitor interactions with serine
RT proteinases.";
RL Biochemistry 21:2274-2284(1982).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- DOMAIN: Avian ovomucoid consists of three homologous, tandem Kazal
CC family inhibitory domains.
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DR PIR; A31446; A31446.
DR AlphaFoldDB; P05587; -.
DR SMR; P05587; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001239; Prot_inh_Kazal-m.
DR Pfam; PF00050; Kazal_1; 1.
DR PRINTS; PR00290; KAZALINHBTR.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR PROSITE; PS00282; KAZAL_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Protease inhibitor; Repeat; Secreted; Serine protease inhibitor.
FT CHAIN <1..>56
FT /note="Ovomucoid"
FT /id="PRO_0000073152"
FT DOMAIN 6..56
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT SITE 18..19
FT /note="Reactive bond 3"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT DISULFID 8..38
FT DISULFID 16..35
FT DISULFID 24..56
FT NON_TER 1
FT NON_TER 56
SQ SEQUENCE 56 AA; 6042 MW; 3AA0D2542C5002E8 CRC64;
FAAVSVDCSE YPKPACTLEY RPLCGSDSKT YANKCNFCNA VVESNGTLTL SHFGKC