ID   IOVO_PAVCR              Reviewed;          56 AA.
AC   P05609;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Ovomucoid;
DE   Flags: Fragment;
OS   Pavo cristatus (Indian peafowl) (Blue peafowl).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Pavo.
OX   NCBI_TaxID=9049;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3828298; DOI=10.1021/bi00375a028;
RA   Laskowski M. Jr., Kato I., Ardelt W., Cook J., Denton A., Empie M.W.,
RA   Kohr W.J., Park S.J., Parks K., Schatzley B.L., Schoenberger O.L.,
RA   Tashiro M., Vichot G., Whatley H.E., Wieczorek A., Wieczorek M.;
RT   "Ovomucoid third domains from 100 avian species: isolation, sequences, and
RT   hypervariability of enzyme-inhibitor contact residues.";
RL   Biochemistry 26:202-221(1987).
RN   [2]
RP   PROTEIN SEQUENCE.
RX   PubMed=7046785; DOI=10.1021/bi00539a002;
RA   Empie M.W., Laskowski M. Jr.;
RT   "Thermodynamics and kinetics of single residue replacements in avian
RT   ovomucoid third domains: effect on inhibitor interactions with serine
RT   proteinases.";
RL   Biochemistry 21:2274-2284(1982).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DOMAIN: Avian ovomucoid consists of three homologous, tandem Kazal
CC       family inhibitory domains.
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DR   PIR; G31440; G31440.
DR   AlphaFoldDB; P05609; -.
DR   BMRB; P05609; -.
DR   SMR; P05609; -.
DR   iPTMnet; P05609; -.
DR   Proteomes; UP000694428; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProt.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR001239; Prot_inh_Kazal-m.
DR   Pfam; PF00050; Kazal_1; 1.
DR   PRINTS; PR00290; KAZALINHBTR.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Protease inhibitor; Reference proteome; Repeat; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           <1..>56
FT                   /note="Ovomucoid"
FT                   /id="PRO_0000073156"
FT   DOMAIN          6..56
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            18..19
FT                   /note="Reactive bond 3"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:3828298"
FT   DISULFID        8..38
FT   DISULFID        16..35
FT   DISULFID        24..56
FT   NON_TER         1
FT   NON_TER         56
SQ   SEQUENCE   56 AA;  5995 MW;  C6C0BE5E2B9B7E55 CRC64;
     LAAVSVDCSE YPKPACTLEH RPLCGSDNKT YGNKCNFCNA VVESNGTLTL SHFGKC