ID   IP13A_DICDI             Reviewed;        1064 AA.
AC   Q54C85;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Importin-13 homolog A;
GN   Name=ipo13A; ORFNames=DDB_G0293110;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for nuclear protein import and mediates docking of
CC       import substrate to distinct nucleoporins. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with an importin alpha subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus envelope
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
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DR   EMBL; AAFI02000199; EAL60907.1; -; Genomic_DNA.
DR   RefSeq; XP_629334.1; XM_629332.1.
DR   AlphaFoldDB; Q54C85; -.
DR   SMR; Q54C85; -.
DR   STRING; 44689.DDB0304413; -.
DR   PaxDb; Q54C85; -.
DR   EnsemblProtists; EAL60907; EAL60907; DDB_G0293110.
DR   GeneID; 8629058; -.
DR   KEGG; ddi:DDB_G0293110; -.
DR   dictyBase; DDB_G0293110; ipo13A.
DR   eggNOG; KOG2022; Eukaryota.
DR   HOGENOM; CLU_288767_0_0_1; -.
DR   InParanoid; Q54C85; -.
DR   OMA; DTFMYCY; -.
DR   PhylomeDB; Q54C85; -.
DR   PRO; PR:Q54C85; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040520; Importin_rep_3.
DR   Pfam; PF18806; Importin_rep_3; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW   Transport.
FT   CHAIN           1..1064
FT                   /note="Importin-13 homolog A"
FT                   /id="PRO_0000328011"
FT   DOMAIN          40..109
FT                   /note="Importin N-terminal"
FT   REGION          695..722
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          839..860
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1064 AA;  121574 MW;  D8FC88DCBD673470 CRC64;
     MYNNNGFHEE TNIDESQFTV EKVETVLKSL YFPQNNDYSA LPQIQQWLIQ FQKSFSSWSI
     APLLLMSNIK EIQYFGASTI ENKIKNNWLS LSQDMKKEFL DNLLLFLKTQ ITKCSTVVIT
     RLCLAVSVIA CHSTTDLWAN PILDVLQLSF QDINNLDCFN PNLVNLTLEL LTIFPEELTN
     ADYITQEKRN KVGLQFNKHN SKVFEILCKI MSLPQNQQTL IFMKSSLKCF KSWILFDCSP
     REYLIDSDLI LKCFEAVSNN PKLVEDFLMV LDEMFTFMGG KIFRSYTSAF SLVLSRILMI
     FPSFYILALQ EENQIFNQIF LLFSHIAENH IKTLLKNPEL SNNFFKALIQ MALKGDFETC
     ELLSPVITEI AALHELHSTS STTEATTTTI ATTTTPTTTS DCDISGWYQY LGEMVEVFRL
     KSMYPLDKDI SDLYEEDAEK FFAFRVIAGD SVLEVYNILE GKILQQLLNS LWSDIQSFPT
     TKCWQSIEAT IYLLSCLSES ITEDTEFVPQ LFSILGQLPI QSTPLIKSTM TLAGNYSNLI
     DKSTIFLEKI VKDFFPAFEN PDLKSVASQS FLSISKNSKC ASILSNSITQ LISLCAPILS
     NNNKILDDPS NFNILEALLY IISTLPSDSQ VLNYSTQLLY PFILFIKNYY TNQLQQQQQQ
     QQQQQTELRL LLSSINLLTK FCKIYDDEQV NEYGTTQQEN NNNNNNNNNN NNNNNNNNNN
     NNNNNIKPVF EIINNIIPIY GELLSLNTLE SSIIEAISIF YKKAIMINNN HQNITNIPEI
     NRQLTLAFLK HKPLSLVLST LSISIVNLPK EQHLDFLADS LSSISSKMIQ IWSEKSNQNN
     KKNNKKINNN IDIDNDNENN NNNNQIQFEN NELNEFKNLK ISIYPDITKE YFTMITQYIR
     YNAVSIPQGV ISHLFSIILV NITKIHDKVT ARACFSFMAL IITKSKEMKS QIKWEPLLNE
     INGWLSIHGE LFIKQILYSA GGGIPRSVVQ FISEVIASLV SSYPDVFRIS ALKCLSVDGF
     PSSNITKEQK EKFLNSLMLY RSKKLPLKIV TDFSLVSLGI ATNQ