IP13B_DICDI
ID IP13B_DICDI Reviewed; 1119 AA.
AC Q54WT9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Importin-13 homolog B;
GN Name=ipo13B; ORFNames=DDB_G0279441;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for nuclear protein import and mediates docking of
CC import substrate to distinct nucleoporins. {ECO:0000250}.
CC -!- SUBUNIT: Forms a complex with an importin alpha subunit. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus envelope
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
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DR EMBL; AAFI02000031; EAL67659.1; -; Genomic_DNA.
DR RefSeq; XP_641628.1; XM_636536.1.
DR AlphaFoldDB; Q54WT9; -.
DR SMR; Q54WT9; -.
DR STRING; 44689.DDB0304414; -.
DR PaxDb; Q54WT9; -.
DR EnsemblProtists; EAL67659; EAL67659; DDB_G0279441.
DR GeneID; 8622034; -.
DR KEGG; ddi:DDB_G0279441; -.
DR dictyBase; DDB_G0279441; ipo13B.
DR eggNOG; KOG2022; Eukaryota.
DR HOGENOM; CLU_288767_0_0_1; -.
DR InParanoid; Q54WT9; -.
DR OMA; ILMNICW; -.
DR PhylomeDB; Q54WT9; -.
DR PRO; PR:Q54WT9; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW Transport.
FT CHAIN 1..1119
FT /note="Importin-13 homolog B"
FT /id="PRO_0000328012"
FT DOMAIN 94..160
FT /note="Importin N-terminal"
FT REPEAT 223..266
FT /note="HEAT 1"
FT REPEAT 336..375
FT /note="HEAT 2"
FT REPEAT 395..434
FT /note="HEAT 3"
FT REPEAT 503..542
FT /note="HEAT 4"
FT REPEAT 545..585
FT /note="HEAT 5"
FT REPEAT 588..625
FT /note="HEAT 6"
FT REPEAT 632..672
FT /note="HEAT 7"
FT REPEAT 717..755
FT /note="HEAT 8"
FT REPEAT 832..851
FT /note="HEAT 9"
FT REPEAT 852..888
FT /note="HEAT 10"
FT REPEAT 931..968
FT /note="HEAT 11"
FT REPEAT 1082..1119
FT /note="HEAT 12"
FT REGION 29..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1119 AA; 127749 MW; A0D74B456A70A230 CRC64;
MNTNAMDQYE NCPSYGSFDV KSFSDSPIPF TNNNNNNNNN NNNNSICVMP SNYNNKNNNN
NNNEKLEPEA TLDVLTHALH TLYKSNDSNQ RKLAEKWLIL FQKQPIAWEF CPRLLLETNI
FELQYFGAST LESKLKNEWN ECNVEMKSKI LNTIVSIIQN STKLPICCVT RVSVTLTIAV
MYTFPEIWRN AIFDIIHLSI KQDINTLSLH DPSQNHFNTD RLLMVLEFLS ILPDELKKQD
LALCKYSEIQ KELKLIIDKI YKFLLSVLFL PINENFEFIK ISYKALSAWL KYMLPSNGTM
LQSCFEISFT VGQQKVSNNS NGNGNGNNNN NNNRNSIGYP LIDSLALVLE GSSLSIEGQS
NGSCYIEAFR YAIEQSLTIF PTFYNEATVM NQDDSKAKPI FNVFVQFISS NNSQLFTTDL
IHRCLNLLIS FIEIGSRETI SLLFYLIDDF KTHTMLVQQD QNILKFFFLK LLNRFLDVSM
YPNGKDYCPI ENGTNPLSTS QNAQFNGVLC ETNIETLLDD DIEQFRSCSS DCLMNIQEND
IIPKSTFLKF LIEKLNAFIN EKCPHWEQYE SILYYIYAFS GGSQDGQLEY VPILLNIIPL
IPIKSIPLVR TSIKLIGRYS SFLKTNTDYL AKVVSDLLPA LSHAELIGSA ASSLLSICVS
DKCSTMLWPH FNQILDQIEP ILLGPQKSNP SIVLVYKSLL HILHKAPIHE LSPLFTRLIS
PVIPNITDHI PRVKSKDHYN QLLVQLSILY SVNEIIEYDE FATMGANGEF TSPSKHPLYP
FFQTTIPIQG QLLKHYKSEF EIIDCITTFY RYMMLYFREI ANDFVDEILQ QATQSFNQYP
IASLLQIISS IIIPKLQPLT ITNIKNSISL ISNTFINTLK SVILATNNNN KNNDNTNNND
DNNNKNDNNN NNNNNDNDKS NFILDFTITP DITKDYLILI TKILKTSPQC IEPNIISTIC
IYIIYNLTDL TKDKPTTGNC CLFLTNCLSL NNGKLQISDP NGNKVLEQIK NEMNALFESD
PKHSYVLVYN ILMNICWTPT SIQVTQHFSD VLLSFAIGYP NLLKLHATNI LNDPNFIKDK
QINPHDKQSF LTNILKSNST QVDYRSSVRT FSFICNDKE
