ID   IP2A_SOLTU              Reviewed;          45 AA.
AC   P01081;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Proteinase inhibitor IIA;
DE   Flags: Fragment;
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=1270410; DOI=10.1093/oxfordjournals.jbchem.a131081;
RA   Iwasaki T., Kiyohara T., Yoshikawa M.;
RT   "Amino acid sequence of an active fragment of potato proteinase inhibitor
RT   IIa.";
RL   J. Biochem. 79:381-391(1976).
CC   -!- FUNCTION: Inhibits trypsin strongly and chymotrypsin temporarily.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I20 (potato type II
CC       proteinase inhibitor) family. {ECO:0000305}.
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DR   PIR; A01320; XKPO2A.
DR   AlphaFoldDB; P01081; -.
DR   SMR; P01081; -.
DR   PRIDE; P01081; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW   Reference proteome; Secreted; Serine protease inhibitor.
FT   CHAIN           <1..>45
FT                   /note="Proteinase inhibitor IIA"
FT                   /id="PRO_0000217675"
FT   SITE            32..33
FT                   /note="Reactive bond for trypsin"
FT   DISULFID        10..24
FT                   /evidence="ECO:0000269|PubMed:1270410"
FT   DISULFID        14..35
FT                   /evidence="ECO:0000269|PubMed:1270410"
FT   DISULFID        20..43
FT                   /evidence="ECO:0000269|PubMed:1270410"
FT   NON_TER         1
FT   NON_TER         45
SQ   SEQUENCE   45 AA;  4955 MW;  E0FD71BF41499F98 CRC64;
     SEGSPENRIC TNNCAGYKGC NYNCDTNIAS YKSVCEGEFD PKCLR