IP5P4_ARATH
ID IP5P4_ARATH Reviewed; 547 AA.
AC Q8GTS0; Q9M1W5;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Type I inositol polyphosphate 5-phosphatase 4 {ECO:0000305};
DE Short=At5PTase4 {ECO:0000305};
DE EC=3.1.3.- {ECO:0000305};
GN Name=IP5P4 {ECO:0000305};
GN OrderedLocusNames=At3g63240 {ECO:0000312|Araport:AT3G63240};
GN ORFNames=F16M2_90 {ECO:0000312|EMBL:CAB86425.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=11402208; DOI=10.1104/pp.126.2.801;
RA Berdy S.E., Kudla J., Gruissem W., Gillaspy G.E.;
RT "Molecular characterization of At5PTase1, an inositol phosphatase capable
RT of terminating inositol trisphosphate signaling.";
RL Plant Physiol. 126:801-810(2001).
CC -!- SIMILARITY: Belongs to the inositol polyphosphate 5-phosphatase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB86425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL138648; CAB86425.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE80454.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64742.1; -; Genomic_DNA.
DR EMBL; AK117957; BAC42595.1; -; mRNA.
DR EMBL; BT005913; AAO64848.1; -; mRNA.
DR PIR; T48113; T48113.
DR RefSeq; NP_001326750.1; NM_001340194.1.
DR RefSeq; NP_191883.2; NM_116189.4.
DR AlphaFoldDB; Q8GTS0; -.
DR SMR; Q8GTS0; -.
DR STRING; 3702.AT3G63240.1; -.
DR PaxDb; Q8GTS0; -.
DR PRIDE; Q8GTS0; -.
DR EnsemblPlants; AT3G63240.1; AT3G63240.1; AT3G63240.
DR EnsemblPlants; AT3G63240.2; AT3G63240.2; AT3G63240.
DR GeneID; 825499; -.
DR Gramene; AT3G63240.1; AT3G63240.1; AT3G63240.
DR Gramene; AT3G63240.2; AT3G63240.2; AT3G63240.
DR KEGG; ath:AT3G63240; -.
DR Araport; AT3G63240; -.
DR TAIR; locus:2077314; AT3G63240.
DR eggNOG; KOG0565; Eukaryota.
DR HOGENOM; CLU_011711_4_0_1; -.
DR InParanoid; Q8GTS0; -.
DR OMA; YAGEGMH; -.
DR OrthoDB; 1399831at2759; -.
DR PhylomeDB; Q8GTS0; -.
DR BioCyc; ARA:AT3G63240-MON; -.
DR PRO; PR:Q8GTS0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8GTS0; baseline and differential.
DR Genevisible; Q8GTS0; AT.
DR GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:InterPro.
DR GO; GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IBA:GO_Central.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IBA:GO_Central.
DR GO; GO:0046855; P:inositol phosphate dephosphorylation; IEA:InterPro.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR Gene3D; 3.60.10.10; -; 2.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR045849; IP5P_plant.
DR InterPro; IPR000300; IPPc.
DR PANTHER; PTHR45666; PTHR45666; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Reference proteome.
FT CHAIN 1..547
FT /note="Type I inositol polyphosphate 5-phosphatase 4"
FT /id="PRO_0000433255"
FT REGION 56..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..402
FT /note="Catalytic 1"
FT /evidence="ECO:0000250|UniProtKB:Q84MA2"
FT REGION 467..482
FT /note="Catalytic 2"
FT /evidence="ECO:0000250|UniProtKB:Q84MA2"
SQ SEQUENCE 547 AA; 62177 MW; 13089EA143883A88 CRC64;
MGDGNLKKSK LSWPKTLVKK WLNIKSKSED FHADDLDRGE GGGDWRNNVI EREEACSVRK
SKTETRSKRN SGRARRNKLD VDPPLDHLRV FTATWNVAGK SPPSYLNLDD WLHTSPPSDI
YVLGFQEIVP LNAGNVLGTE DNGPARKWVS LIRRTLNSLP GGSCQTPSPV PHPVAELDSD
FEGDSAAGAN SLFYHRSRSM RMDASASSLP QQFDRRFSVC DRFMLGDTPD DFYDQSFRYC
SSEDEPADSP CHDHYSPVSR TGSFVADDRD KGRDKSKYCL VASKQMVGIF LTVWVKSDLR
DSVNNLKVSC VGRGLMGYLG NKGSISISMS VHQTSFCFVC SHLTSGQKEG DELRRNSDVL
EILRKTRFPR VNNAGDDKSP QMISEHDRVI WLGDLNYRIA LSYRSAKALV EMRDWRALLE
KDQLRIEQRK GCVFEGWKEG TIYFPPTYKY SNNSDIYAGD DRLPKAKRRT PAWCDRILWH
GSGISQLSYV RGESRFSDHR PVYSLFSVEI ESAYRNRIKK SSSYTSSRIE VEELLPQRYG
YSELNPY
