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IP5P5_ARATH
ID   IP5P5_ARATH             Reviewed;         529 AA.
AC   Q66GQ6; Q9FJQ6;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Type I inositol polyphosphate 5-phosphatase 5 {ECO:0000305};
DE            Short=At5PTase5 {ECO:0000305};
DE            EC=3.1.3.- {ECO:0000305};
DE   AltName: Full=Protein BRISTLED 1 {ECO:0000303|PubMed:11041890};
DE   AltName: Full=Protein DEFORMED ROOT HAIRS 4 {ECO:0000303|PubMed:15863435};
GN   Name=IP5P5 {ECO:0000305};
GN   Synonyms=BST1 {ECO:0000303|PubMed:11041890},
GN   DER4 {ECO:0000303|PubMed:15863435}, MRH3 {ECO:0000303|PubMed:16367956};
GN   OrderedLocusNames=At5g65090 {ECO:0000312|Araport:AT5G65090};
GN   ORFNames=MQN23.2 {ECO:0000312|EMBL:BAB11645.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA   Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT   features of the regions of 1,367,185 bp covered by 19 physically assigned
RT   P1 and TAC clones.";
RL   DNA Res. 5:203-216(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Cheuk R.-F., Kim C.J., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=11041890; DOI=10.2307/3871206;
RA   Parker J.S., Cavell A.C., Dolan L., Roberts K., Grierson C.S.;
RT   "Genetic interactions during root hair morphogenesis in Arabidopsis.";
RL   Plant Cell 12:1961-1974(2000).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=11402208; DOI=10.1104/pp.126.2.801;
RA   Berdy S.E., Kudla J., Gruissem W., Gillaspy G.E.;
RT   "Molecular characterization of At5PTase1, an inositol phosphatase capable
RT   of terminating inositol trisphosphate signaling.";
RL   Plant Physiol. 126:801-810(2001).
RN   [6]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=15863435; DOI=10.1093/pcp/pci115;
RA   Ringli C., Baumberger N., Keller B.;
RT   "The Arabidopsis root hair mutants der2-der9 are affected at different
RT   stages of root hair development.";
RL   Plant Cell Physiol. 46:1046-1053(2005).
RN   [7]
RP   DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=16367956; DOI=10.1111/j.1365-313x.2005.02609.x;
RA   Jones M.A., Raymond M.J., Smirnoff N.;
RT   "Analysis of the root-hair morphogenesis transcriptome reveals the
RT   molecular identity of six genes with roles in root-hair development in
RT   Arabidopsis.";
RL   Plant J. 45:83-100(2006).
CC   -!- FUNCTION: May be involved in the regulation of root hairs development.
CC       Required for restricting both the size of the root-hair initiation site
CC       and the width of the root hairs during the transition to tip growth,
CC       but is not required for normal subsequent tip growth.
CC       {ECO:0000269|PubMed:11041890, ECO:0000269|PubMed:16367956}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q66GQ6-1; Sequence=Displayed;
CC   -!- DISRUPTION PHENOTYPE: Affected root hair morphogenesis.
CC       {ECO:0000269|PubMed:11041890, ECO:0000269|PubMed:15863435,
CC       ECO:0000269|PubMed:16367956}.
CC   -!- SIMILARITY: Belongs to the inositol polyphosphate 5-phosphatase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB11645.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB013395; BAB11645.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED98000.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM70346.1; -; Genomic_DNA.
DR   EMBL; BT015346; AAU05469.1; -; mRNA.
DR   EMBL; BT015797; AAU93569.1; -; mRNA.
DR   RefSeq; NP_001318880.1; NM_001345669.1. [Q66GQ6-1]
DR   RefSeq; NP_201314.3; NM_125908.5. [Q66GQ6-1]
DR   AlphaFoldDB; Q66GQ6; -.
DR   SMR; Q66GQ6; -.
DR   STRING; 3702.AT5G65090.1; -.
DR   iPTMnet; Q66GQ6; -.
DR   PaxDb; Q66GQ6; -.
DR   PRIDE; Q66GQ6; -.
DR   ProteomicsDB; 228845; -. [Q66GQ6-1]
DR   EnsemblPlants; AT5G65090.1; AT5G65090.1; AT5G65090. [Q66GQ6-1]
DR   EnsemblPlants; AT5G65090.3; AT5G65090.3; AT5G65090. [Q66GQ6-1]
DR   GeneID; 836633; -.
DR   Gramene; AT5G65090.1; AT5G65090.1; AT5G65090. [Q66GQ6-1]
DR   Gramene; AT5G65090.3; AT5G65090.3; AT5G65090. [Q66GQ6-1]
DR   KEGG; ath:AT5G65090; -.
DR   Araport; AT5G65090; -.
DR   TAIR; locus:2171805; AT5G65090.
DR   eggNOG; KOG0565; Eukaryota.
DR   InParanoid; Q66GQ6; -.
DR   OrthoDB; 1399831at2759; -.
DR   PhylomeDB; Q66GQ6; -.
DR   BioCyc; ARA:AT5G65090-MON; -.
DR   PRO; PR:Q66GQ6; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q66GQ6; baseline and differential.
DR   Genevisible; Q66GQ6; AT.
DR   GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:InterPro.
DR   GO; GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0009932; P:cell tip growth; IMP:TAIR.
DR   GO; GO:0046855; P:inositol phosphate dephosphorylation; IEA:InterPro.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR   GO; GO:0010053; P:root epidermal cell differentiation; IMP:TAIR.
DR   GO; GO:0048765; P:root hair cell differentiation; IMP:UniProtKB.
DR   GO; GO:0048766; P:root hair initiation; IMP:UniProtKB.
DR   Gene3D; 3.60.10.10; -; 2.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR045849; IP5P_plant.
DR   InterPro; IPR000300; IPPc.
DR   PANTHER; PTHR45666; PTHR45666; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SMART; SM00128; IPPc; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Hydrolase; Reference proteome.
FT   CHAIN           1..529
FT                   /note="Type I inositol polyphosphate 5-phosphatase 5"
FT                   /id="PRO_0000433256"
FT   REGION          371..386
FT                   /note="Catalytic 1"
FT                   /evidence="ECO:0000250|UniProtKB:Q84MA2"
FT   REGION          451..466
FT                   /note="Catalytic 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q84MA2"
SQ   SEQUENCE   529 AA;  59930 MW;  27469CC029A6C54D CRC64;
     MNNRGNNDDL DHHYGVFNDF ERRMTSRKKS VLDNTSPMIW KTVSERKSSP GIEGLNLSSF
     DRPMAPTTEI RELRVFLATW NVGGRTPNND LNLEDFLLVE GTADLYICGF QEIVPLSAGN
     VLVVEDNEPA AKWLALISQA LNKPKQESVY SNAAYSASRT TTCSSSSCGS EESRAPSSLS
     FFQRPNLKVL SRNYRVDSSL LKTCNCPVID TSVGWEARRS KRFSDPSTDS SNNVEPENFR
     VHENFLFDDV PATTKMPGQM SYRLIASKQM VGLFLSVWAR RELIPHISHL RLDSVGRGIM
     GRLGNKGCIA ISMSLHQTSF CFVCSHLASG EKEGDELRRN ADVAEILKHT QFPKLTKNPN
     CHAPERIIDH DRVLWLGDLN YRVALTYEET RVLLEDNDWD TLLERDQLNM ERGAGRVFSG
     FQEGQIFFAP TYKYSQNSDA YAGEMTKSKK KRRTPAWCDR ILWKGEGIEQ LSYIRGESRF
     SDHRPVCAIF AVEVDVKSLN KGRFRKGYSC AAVRLVEDVA IPQRHSFYD
 
 
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