IP5P8_ARATH
ID IP5P8_ARATH Reviewed; 479 AA.
AC Q0WT19; Q9ZUS3;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Type I inositol polyphosphate 5-phosphatase 8 {ECO:0000305};
DE Short=At5PTase8 {ECO:0000305};
DE EC=3.1.3.- {ECO:0000305};
GN Name=IP5P8 {ECO:0000305};
GN OrderedLocusNames=At2g37440 {ECO:0000312|Araport:AT2G37440};
GN ORFNames=F3G5.23 {ECO:0000312|EMBL:AAC98062.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY.
RX PubMed=11402208; DOI=10.1104/pp.126.2.801;
RA Berdy S.E., Kudla J., Gruissem W., Gillaspy G.E.;
RT "Molecular characterization of At5PTase1, an inositol phosphatase capable
RT of terminating inositol trisphosphate signaling.";
RL Plant Physiol. 126:801-810(2001).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q0WT19-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the inositol polyphosphate 5-phosphatase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC98062.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005896; AAC98062.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC09399.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61598.1; -; Genomic_DNA.
DR EMBL; AK227745; BAE99729.1; -; mRNA.
DR PIR; G84792; G84792.
DR RefSeq; NP_001323804.1; NM_001336660.1. [Q0WT19-1]
DR RefSeq; NP_181280.3; NM_129299.4. [Q0WT19-1]
DR AlphaFoldDB; Q0WT19; -.
DR SMR; Q0WT19; -.
DR STRING; 3702.AT2G37440.1; -.
DR PaxDb; Q0WT19; -.
DR PRIDE; Q0WT19; -.
DR EnsemblPlants; AT2G37440.1; AT2G37440.1; AT2G37440. [Q0WT19-1]
DR EnsemblPlants; AT2G37440.3; AT2G37440.3; AT2G37440. [Q0WT19-1]
DR GeneID; 818321; -.
DR Gramene; AT2G37440.1; AT2G37440.1; AT2G37440. [Q0WT19-1]
DR Gramene; AT2G37440.3; AT2G37440.3; AT2G37440. [Q0WT19-1]
DR KEGG; ath:AT2G37440; -.
DR Araport; AT2G37440; -.
DR TAIR; locus:2049826; AT2G37440.
DR eggNOG; KOG0565; Eukaryota.
DR HOGENOM; CLU_011711_4_1_1; -.
DR InParanoid; Q0WT19; -.
DR OMA; RADLMPC; -.
DR PhylomeDB; Q0WT19; -.
DR PRO; PR:Q0WT19; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q0WT19; baseline and differential.
DR Genevisible; Q0WT19; AT.
DR GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:InterPro.
DR GO; GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IBA:GO_Central.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IBA:GO_Central.
DR GO; GO:0046855; P:inositol phosphate dephosphorylation; IEA:InterPro.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR045849; IP5P_plant.
DR InterPro; IPR000300; IPPc.
DR PANTHER; PTHR45666; PTHR45666; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Hydrolase; Reference proteome.
FT CHAIN 1..479
FT /note="Type I inositol polyphosphate 5-phosphatase 8"
FT /id="PRO_0000433258"
FT REGION 300..315
FT /note="Catalytic 1"
FT /evidence="ECO:0000250|UniProtKB:Q84MA2"
FT REGION 379..394
FT /note="Catalytic 2"
FT /evidence="ECO:0000250|UniProtKB:Q84MA2"
SQ SEQUENCE 479 AA; 54621 MW; 5B12959276532422 CRC64;
MGKILKSKSS WPRTVVRKWL NLRSGAYEFH SDYPVKGMEP RRKSCSDMIV PENFQGWLGQ
GNGDLKHSTG EQHVTRVDDK LDLKMFVGTW NVGGKSPHEG LDLKDWLKSP ADADIYVLGF
QEIVPLNAGN VLGAEDNGPA AKWLSLIREA LNNTNNLSPN ELEHTKSSQQ PRFSFSGLSD
DTPIPCNSTP PRGYSLAASK QMVGIFLCVW VRDDLRKRIT NLKVSCVGRG IMGYLGNKGS
VSISMSLHET SLCFVCTHLT SGEKEGDELR RNLDVTEIFK RTRFSRSSKD SRPETIMDHD
KVIWLGDLNY RLRASSDLHE QLRNHDWESL LEKDQLKIEQ RAGRIFKGWE EGKIYFAPTY
KYRINSDNYV VQTEKSKEKR RTPAWCDRIL WKGDGMKQLW YVRGESKFSD HRPVQSLFSV
HIDLKNQSNR KTKPVNQNHR PNPVLTYTCH GKVQAEEILL LTRAQSCIDT LPRLISSAS
