IP5PA_ARATH
ID IP5PA_ARATH Reviewed; 466 AA.
AC A8MR21; F4JXT0; Q9FF76;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Type I inositol polyphosphate 5-phosphatase 10 {ECO:0000305};
DE Short=At5PTase10 {ECO:0000305};
DE EC=3.1.3.- {ECO:0000305};
GN Name=IP5P10 {ECO:0000305};
GN OrderedLocusNames=At5g04980 {ECO:0000312|Araport:AT5G04980};
GN ORFNames=MUG13.16 {ECO:0000312|EMBL:BAB11520.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=11402208; DOI=10.1104/pp.126.2.801;
RA Berdy S.E., Kudla J., Gruissem W., Gillaspy G.E.;
RT "Molecular characterization of At5PTase1, an inositol phosphatase capable
RT of terminating inositol trisphosphate signaling.";
RL Plant Physiol. 126:801-810(2001).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A8MR21-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A8MR21-2; Sequence=VSP_057698;
CC -!- SIMILARITY: Belongs to the inositol polyphosphate 5-phosphatase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11520.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB005245; BAB11520.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED90811.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90812.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70767.1; -; Genomic_DNA.
DR RefSeq; NP_001078529.1; NM_001085060.2. [A8MR21-1]
DR RefSeq; NP_001332351.1; NM_001342799.1. [A8MR21-2]
DR RefSeq; NP_196117.2; NM_120580.3. [A8MR21-2]
DR AlphaFoldDB; A8MR21; -.
DR SMR; A8MR21; -.
DR STRING; 3702.AT5G04980.2; -.
DR PaxDb; A8MR21; -.
DR PRIDE; A8MR21; -.
DR EnsemblPlants; AT5G04980.1; AT5G04980.1; AT5G04980. [A8MR21-2]
DR EnsemblPlants; AT5G04980.2; AT5G04980.2; AT5G04980. [A8MR21-1]
DR EnsemblPlants; AT5G04980.3; AT5G04980.3; AT5G04980. [A8MR21-2]
DR GeneID; 830380; -.
DR Gramene; AT5G04980.1; AT5G04980.1; AT5G04980. [A8MR21-2]
DR Gramene; AT5G04980.2; AT5G04980.2; AT5G04980. [A8MR21-1]
DR Gramene; AT5G04980.3; AT5G04980.3; AT5G04980. [A8MR21-2]
DR KEGG; ath:AT5G04980; -.
DR Araport; AT5G04980; -.
DR TAIR; locus:2175344; AT5G04980.
DR eggNOG; KOG0565; Eukaryota.
DR InParanoid; A8MR21; -.
DR OrthoDB; 1399831at2759; -.
DR PhylomeDB; A8MR21; -.
DR BioCyc; ARA:AT5G04980-MON; -.
DR PRO; PR:A8MR21; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; A8MR21; baseline and differential.
DR Genevisible; A8MR21; AT.
DR GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:InterPro.
DR GO; GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IBA:GO_Central.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IBA:GO_Central.
DR GO; GO:0046855; P:inositol phosphate dephosphorylation; IEA:InterPro.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR Gene3D; 3.60.10.10; -; 2.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR045849; IP5P_plant.
DR InterPro; IPR000300; IPPc.
DR PANTHER; PTHR45666; PTHR45666; 2.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; SSF56219; 2.
PE 3: Inferred from homology;
KW Alternative splicing; Hydrolase; Reference proteome.
FT CHAIN 1..466
FT /note="Type I inositol polyphosphate 5-phosphatase 10"
FT /id="PRO_0000433260"
FT REGION 183..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..345
FT /note="Catalytic 1"
FT /evidence="ECO:0000250|UniProtKB:Q84MA2"
FT REGION 411..426
FT /note="Catalytic 2"
FT /evidence="ECO:0000250|UniProtKB:Q84MA2"
FT COMPBIAS 186..205
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..29
FT /note="Missing (in isoform 2)"
FT /id="VSP_057698"
SQ SEQUENCE 466 AA; 52542 MW; 366DC31ACE0AAA24 CRC64;
MSDPLYIFNR SQSEIVVESL LASSNLRSSM PTQQIQSLRV FVATWNVGGK SPHSGLNLDA
LLHVHSEFDV YVLGFQEIVP LNAGNVLVLG DNEPAAKWLA MINQSLNKSS SSSGGRLSPK
TPSFGAGSMF FAKPSLKKIS ESFRTECRRK LKICNCSTFS EDIVRKYGRE SCFRCPEGLV
NQSGVLSDDE EDEDDDDDDE DEDEGGGKVA SLVSNQMTMK YGLVASKQMV GIFLTVWMRK
ELIQHVSHLR ISSVTRGIMG CLGNKGCIAV SLQLYKTSFC FICSHLASGE REGDERRRNL
DVIEILKNTS FPRICRTSFT RVPDRITKHD RVIWLGDLNY RIALSYSETK TLLDKNAWDT
LLNKDQLKIE RDAGRVFKGW HEGKIFFAPT YKYSYNSDAY AGDTSKEKKN KRRTPAWCDR
ILWHGDGIRQ LSYVRGESRF SDHRPVCSVF VVDVEVCEGK TGTRRQ
