IP6K1_HUMAN
ID IP6K1_HUMAN Reviewed; 441 AA.
AC Q92551; A8K157; A8MUX4; Q7L3I7; Q96E38;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 3.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Inositol hexakisphosphate kinase 1;
DE Short=InsP6 kinase 1;
DE EC=2.7.4.21;
DE AltName: Full=Inositol hexaphosphate kinase 1;
GN Name=IP6K1; Synonyms=IHPK1, KIAA0263;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Bone marrow;
RX PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. VI. The
RT coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of
RT cDNA clones from cell line KG-1 and brain.";
RL DNA Res. 3:321-329(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=11502751; DOI=10.1074/jbc.m106842200;
RA Saiardi A., Nagata E., Luo H.R., Snowman A.M., Snyder S.H.;
RT "Identification and characterization of a novel inositol hexakisphosphate
RT kinase.";
RL J. Biol. Chem. 276:39179-39185(2001).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Converts inositol hexakisphosphate (InsP6) to
CC diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts
CC 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-
CC inositol 1,2,3,4,6-pentakisphosphate + ADP; Xref=Rhea:RHEA:12793,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58130, ChEBI:CHEBI:58628,
CC ChEBI:CHEBI:456216; EC=2.7.4.21;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP +
CC H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate +
CC ADP; Xref=Rhea:RHEA:37467, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:74946, ChEBI:CHEBI:77983, ChEBI:CHEBI:456216;
CC EC=2.7.4.21;
CC -!- INTERACTION:
CC Q92551; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-751911, EBI-10173507;
CC Q92551; Q15024: EXOSC7; NbExp=6; IntAct=EBI-751911, EBI-371841;
CC Q92551; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-751911, EBI-79165;
CC Q92551; P62913-2: RPL11; NbExp=3; IntAct=EBI-751911, EBI-11027771;
CC Q92551; Q14139: UBE4A; NbExp=3; IntAct=EBI-751911, EBI-1048119;
CC Q92551; P08670: VIM; NbExp=3; IntAct=EBI-751911, EBI-353844;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11502751}. Nucleus
CC {ECO:0000269|PubMed:11502751}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q92551-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q92551-2; Sequence=VSP_042756;
CC -!- SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA13393.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; D87452; BAA13393.2; ALT_INIT; mRNA.
DR EMBL; AK289772; BAF82461.1; -; mRNA.
DR EMBL; AK295689; BAG58541.1; -; mRNA.
DR EMBL; AC099668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC139451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC141000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471055; EAW65016.1; -; Genomic_DNA.
DR EMBL; BC012944; AAH12944.1; -; mRNA.
DR CCDS; CCDS33760.1; -. [Q92551-1]
DR CCDS; CCDS43092.1; -. [Q92551-2]
DR RefSeq; NP_001006115.1; NM_001006115.2. [Q92551-2]
DR RefSeq; NP_001229758.1; NM_001242829.1. [Q92551-1]
DR RefSeq; NP_695005.1; NM_153273.3. [Q92551-1]
DR AlphaFoldDB; Q92551; -.
DR BioGRID; 115147; 50.
DR IntAct; Q92551; 17.
DR STRING; 9606.ENSP00000482032; -.
DR BindingDB; Q92551; -.
DR ChEMBL; CHEMBL4523418; -.
DR iPTMnet; Q92551; -.
DR PhosphoSitePlus; Q92551; -.
DR BioMuta; IP6K1; -.
DR DMDM; 50400597; -.
DR EPD; Q92551; -.
DR jPOST; Q92551; -.
DR MassIVE; Q92551; -.
DR MaxQB; Q92551; -.
DR PaxDb; Q92551; -.
DR PeptideAtlas; Q92551; -.
DR PRIDE; Q92551; -.
DR ProteomicsDB; 75309; -. [Q92551-1]
DR ProteomicsDB; 75310; -. [Q92551-2]
DR Antibodypedia; 30640; 247 antibodies from 28 providers.
DR DNASU; 9807; -.
DR Ensembl; ENST00000321599.9; ENSP00000323780.4; ENSG00000176095.12. [Q92551-1]
DR Ensembl; ENST00000395238.5; ENSP00000378659.1; ENSG00000176095.12. [Q92551-2]
DR Ensembl; ENST00000460540.1; ENSP00000420762.1; ENSG00000176095.12. [Q92551-2]
DR Ensembl; ENST00000613416.4; ENSP00000482032.1; ENSG00000176095.12. [Q92551-1]
DR GeneID; 9807; -.
DR KEGG; hsa:9807; -.
DR MANE-Select; ENST00000321599.9; ENSP00000323780.4; NM_153273.4; NP_695005.1.
DR UCSC; uc003cxm.2; human. [Q92551-1]
DR CTD; 9807; -.
DR DisGeNET; 9807; -.
DR GeneCards; IP6K1; -.
DR HGNC; HGNC:18360; IP6K1.
DR HPA; ENSG00000176095; Low tissue specificity.
DR MIM; 606991; gene.
DR neXtProt; NX_Q92551; -.
DR OpenTargets; ENSG00000176095; -.
DR PharmGKB; PA164720982; -.
DR VEuPathDB; HostDB:ENSG00000176095; -.
DR eggNOG; KOG1620; Eukaryota.
DR GeneTree; ENSGT00940000157802; -.
DR HOGENOM; CLU_014862_0_0_1; -.
DR InParanoid; Q92551; -.
DR OMA; HFKLPCV; -.
DR PhylomeDB; Q92551; -.
DR TreeFam; TF314066; -.
DR BioCyc; MetaCyc:HS10997-MON; -.
DR BRENDA; 2.7.4.21; 2681.
DR PathwayCommons; Q92551; -.
DR Reactome; R-HSA-1855167; Synthesis of pyrophosphates in the cytosol.
DR Reactome; R-HSA-1855191; Synthesis of IPs in the nucleus.
DR SignaLink; Q92551; -.
DR BioGRID-ORCS; 9807; 10 hits in 1082 CRISPR screens.
DR ChiTaRS; IP6K1; human.
DR GeneWiki; IHPK1; -.
DR GenomeRNAi; 9807; -.
DR Pharos; Q92551; Tbio.
DR PRO; PR:Q92551; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q92551; protein.
DR Bgee; ENSG00000176095; Expressed in paraflocculus and 173 other tissues.
DR ExpressionAtlas; Q92551; baseline and differential.
DR Genevisible; Q92551; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0001650; C:fibrillar center; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0052836; F:inositol 5-diphosphate pentakisphosphate 5-kinase activity; TAS:Reactome.
DR GO; GO:0052839; F:inositol diphosphate tetrakisphosphate kinase activity; TAS:Reactome.
DR GO; GO:0000829; F:inositol heptakisphosphate kinase activity; TAS:Reactome.
DR GO; GO:0052723; F:inositol hexakisphosphate 1-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0052724; F:inositol hexakisphosphate 3-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000832; F:inositol hexakisphosphate 5-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000828; F:inositol hexakisphosphate kinase activity; IDA:UniProtKB.
DR GO; GO:0000827; F:inositol-1,3,4,5,6-pentakisphosphate kinase activity; TAS:Reactome.
DR GO; GO:0016301; F:kinase activity; IBA:GO_Central.
DR GO; GO:0032958; P:inositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IDA:UniProtKB.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.470.160; -; 1.
DR InterPro; IPR005522; IPK.
DR InterPro; IPR038286; IPK_sf.
DR PANTHER; PTHR12400; PTHR12400; 1.
DR Pfam; PF03770; IPK; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Cytoplasm; Kinase; Nucleotide-binding;
KW Nucleus; Phosphoprotein; Reference proteome; Transferase.
FT CHAIN 1..441
FT /note="Inositol hexakisphosphate kinase 1"
FT /id="PRO_0000066874"
FT REGION 100..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 220..228
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT MOD_RES 151
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VAR_SEQ 1..165
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042756"
SQ SEQUENCE 441 AA; 50236 MW; 6DFB2F88E1F91EE9 CRC64;
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP LISREQRFYE
SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE TVEQDDTTER EQPRRKHSRR
SLHRSGSGSD HKEEKASLSL ETSESSQEAK SPKVELHSHS EVPFQMLDGN SGLSSEKISH
NPWSLRCHKQ QLSRMRSESK DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK
AARQMRKCEQ STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRAESCL DRRSEMRLKH
LDMVLPEVAS SCGPSTSPSN TSPEAGPSSQ PKVDVRMIDF AHSTFKGFRD DPTVHDGPDR
GYVFGLENLI SIMEQMRDEN Q
