IP6K1_MOUSE
ID IP6K1_MOUSE Reviewed; 433 AA.
AC Q6PD10; Q9QXV6;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Inositol hexakisphosphate kinase 1;
DE Short=InsP6 kinase 1;
DE EC=2.7.4.21;
DE AltName: Full=Inositol hexaphosphate kinase 1;
GN Name=Ip6k1; Synonyms=Ihpk1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=10574768; DOI=10.1016/s0960-9822(00)80055-x;
RA Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H.;
RT "Synthesis of diphosphoinositol pentakisphosphate by a newly identified
RT family of higher inositol polyphosphate kinases.";
RL Curr. Biol. 9:1323-1326(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Converts inositol hexakisphosphate (InsP6) to
CC diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts
CC 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
CC {ECO:0000269|PubMed:10574768}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-
CC inositol 1,2,3,4,6-pentakisphosphate + ADP; Xref=Rhea:RHEA:12793,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58130, ChEBI:CHEBI:58628,
CC ChEBI:CHEBI:456216; EC=2.7.4.21;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP +
CC H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate +
CC ADP; Xref=Rhea:RHEA:37467, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:74946, ChEBI:CHEBI:77983, ChEBI:CHEBI:456216;
CC EC=2.7.4.21;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain and testis. Detected at
CC much lower levels in heart, kidney, liver, lung and spleen.
CC {ECO:0000269|PubMed:10574768}.
CC -!- SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.
CC {ECO:0000305}.
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DR EMBL; AF177144; AAF15056.1; -; mRNA.
DR EMBL; BC059006; AAH59006.1; -; mRNA.
DR CCDS; CCDS23514.1; -.
DR RefSeq; NP_038813.2; NM_013785.2.
DR AlphaFoldDB; Q6PD10; -.
DR SMR; Q6PD10; -.
DR BioGRID; 205206; 2.
DR STRING; 10090.ENSMUSP00000035214; -.
DR iPTMnet; Q6PD10; -.
DR PhosphoSitePlus; Q6PD10; -.
DR MaxQB; Q6PD10; -.
DR PaxDb; Q6PD10; -.
DR PRIDE; Q6PD10; -.
DR ProteomicsDB; 269495; -.
DR Antibodypedia; 30640; 247 antibodies from 28 providers.
DR DNASU; 27399; -.
DR Ensembl; ENSMUST00000035214; ENSMUSP00000035214; ENSMUSG00000032594.
DR GeneID; 27399; -.
DR KEGG; mmu:27399; -.
DR UCSC; uc009roc.1; mouse.
DR CTD; 9807; -.
DR MGI; MGI:1351633; Ip6k1.
DR VEuPathDB; HostDB:ENSMUSG00000032594; -.
DR eggNOG; KOG1620; Eukaryota.
DR GeneTree; ENSGT00940000157802; -.
DR HOGENOM; CLU_014862_0_0_1; -.
DR InParanoid; Q6PD10; -.
DR OMA; HFKLPCV; -.
DR OrthoDB; 1102768at2759; -.
DR PhylomeDB; Q6PD10; -.
DR TreeFam; TF314066; -.
DR BRENDA; 2.7.1.158; 3474.
DR BRENDA; 2.7.4.21; 3474.
DR Reactome; R-MMU-1855167; Synthesis of pyrophosphates in the cytosol.
DR Reactome; R-MMU-1855191; Synthesis of IPs in the nucleus.
DR SABIO-RK; Q6PD10; -.
DR BioGRID-ORCS; 27399; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Ip6k1; mouse.
DR PRO; PR:Q6PD10; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q6PD10; protein.
DR Bgee; ENSMUSG00000032594; Expressed in spermatid and 257 other tissues.
DR ExpressionAtlas; Q6PD10; baseline and differential.
DR Genevisible; Q6PD10; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0052723; F:inositol hexakisphosphate 1-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0052724; F:inositol hexakisphosphate 3-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000832; F:inositol hexakisphosphate 5-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000828; F:inositol hexakisphosphate kinase activity; ISO:MGI.
DR GO; GO:0000827; F:inositol-1,3,4,5,6-pentakisphosphate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IBA:GO_Central.
DR GO; GO:0006020; P:inositol metabolic process; ISO:MGI.
DR GO; GO:0032958; P:inositol phosphate biosynthetic process; ISO:MGI.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IMP:YuBioLab.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; ISS:UniProtKB.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.470.160; -; 1.
DR InterPro; IPR005522; IPK.
DR InterPro; IPR038286; IPK_sf.
DR PANTHER; PTHR12400; PTHR12400; 1.
DR Pfam; PF03770; IPK; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Transferase.
FT CHAIN 1..433
FT /note="Inositol hexakisphosphate kinase 1"
FT /id="PRO_0000066875"
FT REGION 100..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 220..228
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT MOD_RES 151
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92551"
FT CONFLICT 428..429
FT /note="MR -> VP (in Ref. 1; AAF15056)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 433 AA; 49307 MW; 30BDF7B9DD473607 CRC64;
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP LISREQRFYE
SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE TVEQDDTPER EQPRRKHSRR
SLHRSGSGSD HKEEKASLSF ETSESSQEAK SPKVELHSHS DVPFQMLDSN SGLSSEKISY
NPWSLRCHKQ QLSRMRSESK DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK
AARQMRKCEQ STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL KHVDMGLPEV
PPPCGPSTSP SSTSLEAGPS SPPKVDVRMI DFAHSTFKGF RDDPTVHDGP DRGYVFGLEN
LISIMEQMRD ENQ
