IP6K1_RAT
ID IP6K1_RAT Reviewed; 433 AA.
AC Q9ESM0;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Inositol hexakisphosphate kinase 1;
DE Short=InsP6 kinase 1;
DE EC=2.7.4.21;
DE AltName: Full=Inositol hexaphosphate kinase 1;
GN Name=Ip6k1; Synonyms=Ihpk1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Brain;
RA Ohyama T., Matsuda K., Tachibana H., Horikawa Y., Sakata S.F., Tamaki N.;
RT "Cloning and sequencing of rat inositol hexakisphosphate kinase cDNA.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Converts inositol hexakisphosphate (InsP6) to
CC diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts
CC 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-
CC inositol 1,2,3,4,6-pentakisphosphate + ADP; Xref=Rhea:RHEA:12793,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58130, ChEBI:CHEBI:58628,
CC ChEBI:CHEBI:456216; EC=2.7.4.21;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP +
CC H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate +
CC ADP; Xref=Rhea:RHEA:37467, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:74946, ChEBI:CHEBI:77983, ChEBI:CHEBI:456216;
CC EC=2.7.4.21;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.
CC {ECO:0000305}.
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DR EMBL; AB049151; BAB13737.1; -; mRNA.
DR EMBL; BC078702; AAH78702.1; -; mRNA.
DR RefSeq; NP_445768.1; NM_053316.2.
DR RefSeq; XP_006243901.1; XM_006243839.1.
DR AlphaFoldDB; Q9ESM0; -.
DR SMR; Q9ESM0; -.
DR STRING; 10116.ENSRNOP00000044935; -.
DR PaxDb; Q9ESM0; -.
DR PRIDE; Q9ESM0; -.
DR GeneID; 50560; -.
DR KEGG; rno:50560; -.
DR UCSC; RGD:71025; rat.
DR CTD; 9807; -.
DR RGD; 71025; Ip6k1.
DR eggNOG; KOG1620; Eukaryota.
DR HOGENOM; CLU_014862_0_0_1; -.
DR InParanoid; Q9ESM0; -.
DR OMA; HFKLPCV; -.
DR OrthoDB; 1102768at2759; -.
DR PhylomeDB; Q9ESM0; -.
DR TreeFam; TF314066; -.
DR Reactome; R-RNO-1855167; Synthesis of pyrophosphates in the cytosol.
DR Reactome; R-RNO-1855191; Synthesis of IPs in the nucleus.
DR PRO; PR:Q9ESM0; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000019932; Expressed in testis and 18 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0052723; F:inositol hexakisphosphate 1-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0052724; F:inositol hexakisphosphate 3-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000832; F:inositol hexakisphosphate 5-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000828; F:inositol hexakisphosphate kinase activity; ISO:RGD.
DR GO; GO:0000827; F:inositol-1,3,4,5,6-pentakisphosphate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IBA:GO_Central.
DR GO; GO:0032958; P:inositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; ISS:UniProtKB.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.470.160; -; 1.
DR InterPro; IPR005522; IPK.
DR InterPro; IPR038286; IPK_sf.
DR PANTHER; PTHR12400; PTHR12400; 1.
DR Pfam; PF03770; IPK; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Transferase.
FT CHAIN 1..433
FT /note="Inositol hexakisphosphate kinase 1"
FT /id="PRO_0000066876"
FT REGION 100..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 220..228
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT MOD_RES 151
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92551"
SQ SEQUENCE 433 AA; 49366 MW; 31F6A9E4DA592943 CRC64;
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP LISREQRFYE
SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE TVEQDDTPER EQPRRKHSRR
SLHRSGSGSD HKEEKASLSF ETSESSQETK SPKVELHSHS DVPFQMLDSN SGLSSEKISY
NPWSLRCHKQ QLSRMRSESK DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK
AARQMRKCEQ STSASLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL KHVDMGLPEV
PPLCGPSTSP SNTSLEAGPS SPPKVDVRMI DFAHSTFKGF RDDPTVHDGP DRGYVFGLEN
LISIMEQMRD ENQ
