IP6K2_RAT
ID IP6K2_RAT Reviewed; 425 AA.
AC Q9R0U1; Q5XIU6;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Inositol hexakisphosphate kinase 2;
DE Short=InsP6 kinase 2;
DE EC=2.7.4.- {ECO:0000250|UniProtKB:Q9UHH9};
DE AltName: Full=P(i)-uptake stimulator {ECO:0000303|PubMed:10527952};
DE Short=PiUS {ECO:0000303|PubMed:10527952};
GN Name=Ip6k2; Synonyms=Ihpk2, Pius;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PRELIMINARY FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Small intestine;
RX PubMed=10527952; DOI=10.1042/bj3430705;
RA Katai K., Miyamoto K., Kishida S., Segawa H., Nii T., Tanaka H., Tani Y.,
RA Arai H., Tatsumi S., Morita K., Taketani Y., Takeda E.;
RT "Regulation of intestinal Na+-dependent phosphate co-transporters by a low-
RT phosphate diet and 1,25-dihydroxyvitamin D3.";
RL Biochem. J. 343:705-712(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Converts inositol hexakisphosphate (InsP6) to
CC diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).
CC {ECO:0000250|UniProtKB:Q9UHH9}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-
CC inositol 1,2,3,4,6-pentakisphosphate + ADP; Xref=Rhea:RHEA:12793,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58130, ChEBI:CHEBI:58628,
CC ChEBI:CHEBI:456216;
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylinositol metabolism.
CC {ECO:0000250|UniProtKB:Q9UHH9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UHH9}.
CC -!- TISSUE SPECIFICITY: Highly expressed in small intestine.
CC {ECO:0000269|PubMed:10527952}.
CC -!- SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.
CC {ECO:0000305}.
CC -!- CAUTION: Was first identified because of its ability to stimulate
CC Na(+)-dependent phosphate cotransport. {ECO:0000269|PubMed:10527952}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA87611.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};
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DR EMBL; AB015723; BAA87611.1; ALT_SEQ; mRNA.
DR EMBL; BC083574; AAH83574.1; -; mRNA.
DR RefSeq; NP_067692.2; NM_021660.2.
DR RefSeq; XP_008764786.1; XM_008766564.2.
DR AlphaFoldDB; Q9R0U1; -.
DR SMR; Q9R0U1; -.
DR STRING; 10116.ENSRNOP00000027584; -.
DR PhosphoSitePlus; Q9R0U1; -.
DR PaxDb; Q9R0U1; -.
DR Ensembl; ENSRNOT00000077078; ENSRNOP00000071056; ENSRNOG00000020361.
DR GeneID; 59268; -.
DR KEGG; rno:59268; -.
DR UCSC; RGD:620529; rat.
DR CTD; 51447; -.
DR RGD; 620529; Ip6k2.
DR eggNOG; KOG1620; Eukaryota.
DR GeneTree; ENSGT00940000156310; -.
DR InParanoid; Q9R0U1; -.
DR OMA; CEPKSKV; -.
DR OrthoDB; 902814at2759; -.
DR PhylomeDB; Q9R0U1; -.
DR Reactome; R-RNO-1855191; Synthesis of IPs in the nucleus.
DR UniPathway; UPA00949; -.
DR PRO; PR:Q9R0U1; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000020361; Expressed in ovary and 20 other tissues.
DR Genevisible; Q9R0U1; RN.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0097243; F:flavonoid binding; ISS:UniProtKB.
DR GO; GO:0000832; F:inositol hexakisphosphate 5-kinase activity; ISS:UniProtKB.
DR GO; GO:0000828; F:inositol hexakisphosphate kinase activity; ISO:RGD.
DR GO; GO:0016301; F:kinase activity; IBA:GO_Central.
DR GO; GO:1905396; P:cellular response to flavonoid; ISS:UniProtKB.
DR GO; GO:0032958; P:inositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0043647; P:inositol phosphate metabolic process; ISS:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; ISO:RGD.
DR GO; GO:0006817; P:phosphate ion transport; IDA:RGD.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; ISO:RGD.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
DR Gene3D; 3.30.470.160; -; 1.
DR InterPro; IPR005522; IPK.
DR InterPro; IPR038286; IPK_sf.
DR PANTHER; PTHR12400; PTHR12400; 1.
DR Pfam; PF03770; IPK; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Lipid metabolism; Nucleotide-binding; Nucleus;
KW Phospholipid metabolism; Reference proteome; Transferase.
FT CHAIN 1..425
FT /note="Inositol hexakisphosphate kinase 2"
FT /id="PRO_0000066880"
FT BINDING 206..208
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:Q8NFU5"
FT BINDING 215..223
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 219
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:Q8NFU5"
FT BINDING 221
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q8NFU5"
FT BINDING 235..242
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q8NFU5"
FT BINDING 382
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:Q8NFU5"
FT BINDING 385
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q8NFU5"
SQ SEQUENCE 425 AA; 49164 MW; 6E44C1D3D6EA7FD8 CRC64;
MSPAFRTMDV EPRTKGILLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR
RFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGPVDIVD NSDCEPKSKL LRWTNKKHHV
LETEKSPKDW VRQHRKEEKM KSHKLEEEFE WLKKSEVLYY SVEKKGTVSS QLKHYNPWSM
KCHQQQLQRM KENAKHRNQY KFILLENLTC RYEVPCVLDL KMGTRQHGDD ASEEKAANQI
RKCQQSTSAV IGVRVCGMQV YQAGTGQLMF MNKYHGRKLS VQGFKEALFQ FFHNGRYLRR
ELLGPVLKKL TELKAVLERQ ESYRFYSSSL LVIYDGKEWP EVTLDSDAED LEDLSEESAD
ESAGAYAYKP LGASSVDVRM IDFAHTTCRL YGEDSVVHEG QDAGYIFGLQ SLIDIVTEIS
EESGE
