ID   IPAB_SHIDY              Reviewed;         580 AA.
AC   Q03945;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Invasin IpaB;
DE   AltName: Full=62 kDa antigen;
GN   Name=ipaB;
OS   Shigella dysenteriae.
OG   Plasmid Invasion.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=622;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CG097;
RX   PubMed=1766387; DOI=10.1111/j.1365-2958.1991.tb02151.x;
RA   Yao R., Palchaudhuri S.;
RT   "Nucleotide sequence of the ipaBCD structural genes of Shigella
RT   dysenteriae.";
RL   Mol. Microbiol. 5:2217-2221(1991).
CC   -!- FUNCTION: Associated with the entry of the bacteria into colonic
CC       epithelial cells.
CC   -!- SUBCELLULAR LOCATION: Secreted. Host cell membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}. Note=Secreted through a
CC       type-III system. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X60777; CAA43190.1; -; Genomic_DNA.
DR   PIR; S15577; S15577.
DR   AlphaFoldDB; Q03945; -.
DR   SMR; Q03945; -.
DR   TCDB; 1.C.36.3.1; the bacterial type iii-target cell pore (iiitcp) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR032391; SipB_N.
DR   InterPro; IPR006972; SseC.
DR   InterPro; IPR003895; T3SS_invasion_prot_B.
DR   Pfam; PF04888; SseC; 1.
DR   Pfam; PF16535; T3SSipB; 1.
DR   PRINTS; PR01375; BACINVASINB.
PE   3: Inferred from homology;
KW   Host cell membrane; Host membrane; Membrane; Plasmid; Secreted;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..580
FT                   /note="Invasin IpaB"
FT                   /id="PRO_0000084219"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   580 AA;  62170 MW;  42622989BB049333 CRC64;
     MHNVNTTTTG LSLAKILAST ELGDNTIQAG NDAANKLFSL TIADLTANKN INTTNAHSTS
     NILIPELKAP KSLNASSQLT LLIGNLIQIL GEKSLTALTN KITAWKSQQQ ARQQKNLEFS
     DKINTLLSET EGLTRDYEKQ INKLKNADSK IKDLENKINQ IQTRLSELDP DSPEKKKLSR
     EEIQLTIKKD AAVKDRTLIE QKTLSIHSKL TDKSMQLEKE IDSFSAFSNT ASAEQLSTQQ
     KSLTGLASVT QLMATFIQLV GKNNEESLKN DLALFQSLQE SRKTEMERKS DEYAAEVRKA
     EELNRVMGCV GKILGALLTI VSVVAAAFSG GASLALADVG LALMVTDAIV QAATGNSFME
     QALNPIMKAV IEPLIKLLSD AFTKMLEGLG VDSKKAKMIG SILGAIAGAL VLVAAVVLVA
     TVGKQAAAKL AENIGKIIGK TLTDLIPKFL KNFSSQLDDL ITNAVARLNK FLGAAGDEVI
     SKQIISTHLN QAVLLGESVN SATQAGGSVA SAVFQNSAST NLADLTLSKY QVEQLSKYIS
     EAIEKFGQLQ EVIADLLASM SNSQANRTDV AKAILQQTTA