ID   IPAC_SHIDY              Reviewed;         363 AA.
AC   Q03946;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Invasin IpaC;
DE   AltName: Full=42 kDa antigen;
GN   Name=ipaC;
OS   Shigella dysenteriae.
OG   Plasmid Invasion.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=622;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CG097;
RX   PubMed=1766387; DOI=10.1111/j.1365-2958.1991.tb02151.x;
RA   Yao R., Palchaudhuri S.;
RT   "Nucleotide sequence of the ipaBCD structural genes of Shigella
RT   dysenteriae.";
RL   Mol. Microbiol. 5:2217-2221(1991).
CC   -!- FUNCTION: Associated with the entry of the bacteria into colonic
CC       epithelial cells.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted through a
CC       specialized type-III system. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the invasin protein C family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA43191.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X60777; CAA43191.1; ALT_INIT; Genomic_DNA.
DR   PIR; S15578; S15578.
DR   AlphaFoldDB; Q03946; -.
DR   PRIDE; Q03946; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR005427; BacInvasinC.
DR   Pfam; PF09599; IpaC_SipC; 1.
DR   TIGRFAMs; TIGR02101; IpaC_SipC; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Plasmid; Secreted; Virulence.
FT   CHAIN           1..363
FT                   /note="Invasin IpaC"
FT                   /id="PRO_0000219857"
SQ   SEQUENCE   363 AA;  38836 MW;  E1C844DE8D08CC87 CRC64;
     MEIQNTKSTQ ILYTDISTKQ TQSSSETQKS QNYQQIAAHI PLNVGKNPVL TTTLNDDQLL
     KLSEQVQHDS EIIARLTDKK MKDLSEMSHT LTPENTLDIS SLSSNAVSLI ISVAVLLSAL
     RTAETKLGSQ LSLIAFDATK SAAENIVRQG LAALSSSITG AVTQVGITGI GAKKTHSGIS
     DQKGALRKNL ATAQSLEKEL AGSKLGLNKQ IDTNITSPQT NSSTKFLGKN KLAPDNISLS
     TEHKTSLSSP DISLQDKIDT QRRTYELNTL SAQQKQNIGR ATMETSAVAG NISTSGGRYA
     SALEEEEQLI SQASSKQAEE ASQVSKEASQ ATNQLIQKLL NIIDNINQSR SSTASQIAGN
     IRA