ID   IPCS_ORYSI              Reviewed;         326 AA.
AC   B8ACH9;
DT   31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Phosphatidylinositol:ceramide inositolphosphotransferase;
DE            EC=2.7.8.-;
DE   AltName: Full=Inositol-phosphorylceramide synthase;
DE            Short=IPC synthase;
DE   AltName: Full=Protein ENHANCING RPW8-MEDIATED HR-LIKE CELL DEATH 1;
DE   AltName: Full=Sphingolipid synthase;
GN   Name=ERH1; ORFNames=OsI_04443;
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
CC   -!- FUNCTION: Catalyzes the transfer of the phosphorylinositol group from
CC       phosphatidylinositol (PI) to phytoceramide, an essential step in
CC       sphingolipid biosynthesis. May play an important role in modulating
CC       plant programmed cell death (PCD) associated with defense (e.g. toward
CC       Golovinomyces cichoracearum) by promoting sphingolipid metabolism and
CC       regulating ceramide accumulation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC       {ECO:0000305}.
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DR   EMBL; CM000126; EEC71808.1; -; Genomic_DNA.
DR   AlphaFoldDB; B8ACH9; -.
DR   STRING; 39946.B8ACH9; -.
DR   EnsemblPlants; BGIOSGA004805-TA; BGIOSGA004805-PA; BGIOSGA004805.
DR   Gramene; BGIOSGA004805-TA; BGIOSGA004805-PA; BGIOSGA004805.
DR   HOGENOM; CLU_078641_1_0_1; -.
DR   OMA; QINGMIM; -.
DR   Proteomes; UP000007015; Chromosome 1.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR045221; Sphingomyelin_synth-like.
DR   InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR   PANTHER; PTHR21290; PTHR21290; 1.
DR   Pfam; PF14360; PAP2_C; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Lipid biosynthesis; Lipid metabolism; Membrane;
KW   Plant defense; Reference proteome; Sphingolipid metabolism; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..326
FT                   /note="Phosphatidylinositol:ceramide
FT                   inositolphosphotransferase"
FT                   /id="PRO_0000419959"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          306..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        181
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        222
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        226
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   326 AA;  37555 MW;  119AE8AA00D7841A CRC64;
     MAVYIAREAT KLWRKVCAEI AVELQLLFEK WRLLLAGLVF QYIHGLAARG VHYLHRPGPL
     LQDLGFMALP ELGQDKGYVS ESVFTFIFIS FLLWSFHPFI YHSKRFYTVL LWRRVLAFLV
     ASQFLRIITF YSTQLPGPNY HCREGSKMAT LPPPHNVLEV LLINFPRGVL FGCGDLIFSS
     HMIFTLVFVR TYHKYGSKRL IKILAWLMAI IQSLLIIASR KHYSVDVVVA WYTVNLVVFF
     IDNKLPEMPD RTNGSSLLPV TAKDKDGRTK EELHKLEKDC KMKEEFHKLL NGNTVDSTDR
     RQRVQMNGKH GEDINHTLSD ATPNGT