ID   IPGA_SHIFL              Reviewed;         129 AA.
AC   P33547;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Chaperone protein IpgA;
GN   Name=ipgA; OrderedLocusNames=CP0131;
OS   Shigella flexneri.
OG   Plasmid pWR100, Plasmid pCP301, and Plasmid pINV_F6_M1382.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=1495389; DOI=10.1111/j.1365-2958.1992.tb00885.x;
RA   Allaoui A., Mounier J., Prevost M.-C., Sansonetti P.J., Parsot C.;
RT   "icsB: a Shigella flexneri virulence gene necessary for the lysis of
RT   protrusions during intercellular spread.";
RL   Mol. Microbiol. 6:1605-1616(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=11115111; DOI=10.1046/j.1365-2958.2000.02179.x;
RA   Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H.,
RA   Kunst F., Sansonetti P.J., Parsot C.;
RT   "The virulence plasmid pWR100 and the repertoire of proteins secreted by
RT   the type III secretion apparatus of Shigella flexneri.";
RL   Mol. Microbiol. 38:760-771(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=11292750; DOI=10.1128/iai.69.5.3271-3285.2001;
RA   Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V.,
RA   Blattner F.R.;
RT   "Complete DNA sequence and analysis of the large virulence plasmid of
RT   Shigella flexneri.";
RL   Infect. Immun. 69:3271-3285(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a; PLASMID=pCP301;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M1382 / Serotype 6; PLASMID=pINV_F6_M1382;
RX   PubMed=14573649; DOI=10.1128/iai.71.11.6298-6306.2003;
RA   Lan R., Stevenson G., Reeves P.R.;
RT   "Comparison of two major forms of the Shigella virulence plasmid pINV:
RT   positive selection is a major force driving the divergence.";
RL   Infect. Immun. 71:6298-6306(2003).
RN   [6]
RP   FUNCTION.
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12753186; DOI=10.1046/j.1365-2958.2003.03489.x;
RA   Ogawa M., Suzuki T., Tatsuno I., Abe H., Sasakawa C.;
RT   "IcsB, secreted via the type III secretion system, is chaperoned by IpgA
RT   and required at the post-invasion stage of Shigella pathogenicity.";
RL   Mol. Microbiol. 48:913-931(2003).
CC   -!- FUNCTION: Molecular chaperone required for IcsB stabilization and
CC       secretion. {ECO:0000269|PubMed:12753186}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- MISCELLANEOUS: The icsB gene can be read-through into the ipgA gene to
CC       create a translational fusion protein. The biological significance of
CC       this process is unclear.
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DR   EMBL; M86530; AAD15222.1; -; Genomic_DNA.
DR   EMBL; AL391753; CAC05806.1; -; Genomic_DNA.
DR   EMBL; AF348706; AAK18449.1; -; Genomic_DNA.
DR   EMBL; AF386526; AAL72343.1; -; Genomic_DNA.
DR   EMBL; AY206439; AAP78994.1; -; Genomic_DNA.
DR   PIR; S22688; S22688.
DR   RefSeq; NP_085293.1; NC_002698.1.
DR   RefSeq; NP_858264.1; NC_004851.1.
DR   RefSeq; WP_010921664.1; NZ_WPGS01000043.1.
DR   RefSeq; YP_009062488.1; NC_024996.1.
DR   AlphaFoldDB; P33547; -.
DR   STRING; 198214.CP0131; -.
DR   EnsemblBacteria; AAL72343; AAL72343; SF_p0131.
DR   GeneID; 1238046; -.
DR   KEGG; sfl:CP0131; -.
DR   PATRIC; fig|198214.7.peg.5385; -.
DR   HOGENOM; CLU_1947354_0_0_6; -.
DR   Proteomes; UP000001006; Plasmid pCP301.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Chaperone; Cytoplasm; Plasmid; Reference proteome; Virulence.
FT   CHAIN           1..129
FT                   /note="Chaperone protein IpgA"
FT                   /id="PRO_0000084220"
SQ   SEQUENCE   129 AA;  15085 MW;  8780F5B428A78847 CRC64;
     MCRKLYDKLY EITGAKLDFN DKNQAFILLE EQIPVCITDN DEYIFLTGLL NEHELFTENI
     INPEHILILN YSLSRDYGSS ICLLPDTHQC VLTKKHYKKY LSPDELIESL YEFLFCIKLT
     IANITSEVN