ID   IPGE_SHIFL              Reviewed;         120 AA.
AC   Q6XVY3; Q07567;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Chaperone protein IpgE;
GN   Name=ipgE; OrderedLocusNames=CP0134;
OS   Shigella flexneri.
OG   Plasmid pWR100, Plasmid pCP301, and Plasmid pINV_F6_M1382.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=8478058; DOI=10.1128/iai.61.5.1707-1714.1993;
RA   Allaoui A., Menard R., Sansonetti P.J., Parsot C.;
RT   "Characterization of the Shigella flexneri ipgD and ipgF genes, which are
RT   located in the proximal part of the mxi locus.";
RL   Infect. Immun. 61:1707-1714(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=11115111; DOI=10.1046/j.1365-2958.2000.02179.x;
RA   Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H.,
RA   Kunst F., Sansonetti P.J., Parsot C.;
RT   "The virulence plasmid pWR100 and the repertoire of proteins secreted by
RT   the type III secretion apparatus of Shigella flexneri.";
RL   Mol. Microbiol. 38:760-771(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=11292750; DOI=10.1128/iai.69.5.3271-3285.2001;
RA   Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V.,
RA   Blattner F.R.;
RT   "Complete DNA sequence and analysis of the large virulence plasmid of
RT   Shigella flexneri.";
RL   Infect. Immun. 69:3271-3285(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a; PLASMID=pCP301;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M1382 / Serotype 6; PLASMID=pINV_F6_M1382;
RX   PubMed=14573649; DOI=10.1128/iai.71.11.6298-6306.2003;
RA   Lan R., Stevenson G., Reeves P.R.;
RT   "Comparison of two major forms of the Shigella virulence plasmid pINV:
RT   positive selection is a major force driving the divergence.";
RL   Infect. Immun. 71:6298-6306(2003).
RN   [6]
RP   PROTEIN SEQUENCE OF 1-5, AND FUNCTION.
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=11029686; DOI=10.1046/j.1365-2958.2000.02041.x;
RA   Niebuhr K., Jouihri N., Allaoui A., Gounon P., Sansonetti P.J., Parsot C.;
RT   "IpgD, a protein secreted by the type III secretion machinery of Shigella
RT   flexneri, is chaperoned by IpgE and implicated in entry focus formation.";
RL   Mol. Microbiol. 38:8-19(2000).
CC   -!- FUNCTION: Molecular chaperone required for IpgD stabilization and
CC       secretion. {ECO:0000269|PubMed:11029686}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the IpgE/SigE chaperone family. {ECO:0000305}.
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DR   EMBL; L04309; AAA26518.1; -; Genomic_DNA.
DR   EMBL; AL391753; CAC05809.1; -; Genomic_DNA.
DR   EMBL; AF348706; AAK18453.1; -; Genomic_DNA.
DR   EMBL; AF386526; AAL72338.1; -; Genomic_DNA.
DR   EMBL; AY206439; AAP78997.1; -; Genomic_DNA.
DR   RefSeq; NP_085297.1; NC_002698.1.
DR   RefSeq; NP_858267.1; NC_004851.1.
DR   RefSeq; WP_000389732.1; NZ_WPGS01000043.1.
DR   RefSeq; YP_009062491.1; NC_024996.1.
DR   AlphaFoldDB; Q6XVY3; -.
DR   SMR; Q6XVY3; -.
DR   STRING; 198214.CP0134; -.
DR   EnsemblBacteria; AAL72338; AAL72338; SF_p0134.
DR   GeneID; 1238041; -.
DR   KEGG; sfl:CP0134; -.
DR   PATRIC; fig|623.157.peg.5368; -.
DR   HOGENOM; CLU_2048158_0_0_6; -.
DR   OMA; DDEIQVY; -.
DR   Proteomes; UP000001006; Plasmid pCP301.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd17022; T3SC_IA_SigE-like; 1.
DR   InterPro; IPR013095; T3SS_chaperone.
DR   Pfam; PF07824; Chaperone_III; 1.
DR   PIRSF; PIRSF034754; T3SS_chaperone; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Cytoplasm; Direct protein sequencing; Plasmid;
KW   Reference proteome; Virulence.
FT   CHAIN           1..120
FT                   /note="Chaperone protein IpgE"
FT                   /id="PRO_0000160570"
FT   VARIANT         16
FT                   /note="L -> S (in plasmid pINV_F6_M1382)"
FT   VARIANT         19
FT                   /note="I -> T (in plasmid pINV_F6_M1382)"
FT   VARIANT         79
FT                   /note="N -> S (in plasmid pINV_F6_M1382)"
FT   VARIANT         95
FT                   /note="V -> I (in plasmid pINV_F6_M1382)"
SQ   SEQUENCE   120 AA;  13733 MW;  9FE59A01F7305FBD CRC64;
     MEDLADVICR ALGIPLIDID DQAIMLDDDV LIYIEKEGDS INLLCPFCAL PENINDLIYA
     LSLNYSEKIC LATDDEGGNL IARLDLTGIN EFEDVYVNTE YYISRVRWLK DEFARRMKGY