ID   IPHP_NOSCO              Reviewed;         294 AA.
AC   Q05918;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Tyrosine-protein phosphatase;
DE            EC=3.1.3.48;
DE   Flags: Precursor;
GN   Name=iphP; Synonyms=iph;
OS   Nostoc commune.
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=1178;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 25-37.
RC   STRAIN=UTEX 584 / SAG 1453-5;
RX   PubMed=7681825; DOI=10.1016/s0021-9258(18)53002-7;
RA   Potts M., Sun H., Mockaitis K., Kennelly P.J., Reed D., Tonks N.K.;
RT   "A protein-tyrosine/serine phosphatase encoded by the genome of the
RT   cyanobacterium Nostoc commune UTEX 584.";
RL   J. Biol. Chem. 268:7632-7635(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=UTEX 584 / SAG 1453-5;
RX   PubMed=2536677; DOI=10.1128/jb.171.2.708-713.1989;
RA   Xie W.-Q., Whitton B.A., Simon J.W., Jaeger K., Reed D., Potts M.;
RT   "Nostoc commune UTEX 584 gene expressing indole phosphate hydrolase
RT   activity in Escherichia coli.";
RL   J. Bacteriol. 171:708-713(1989).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU10044};
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       {ECO:0000305}.
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DR   EMBL; L11392; AAA25511.1; -; Genomic_DNA.
DR   PIR; A46635; A46635.
DR   AlphaFoldDB; Q05918; -.
DR   SMR; Q05918; -.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR026893; Tyr/Ser_Pase_IphP-type.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   Pfam; PF13350; Y_phosphatase3; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Protein phosphatase; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:7681825"
FT   CHAIN           25..294
FT                   /note="Tyrosine-protein phosphatase"
FT                   /id="PRO_0000025473"
FT   REGION          221..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..248
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        182
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10044"
SQ   SEQUENCE   294 AA;  31005 MW;  9E067BC99D7EF2B5 CRC64;
     MKTHHANLAL ALMLGLSSSA TAVAADAPQA VATKAAAPNV KPVAADAHGV IPDGAPGMCA
     RSPACRATAI PADAFVRTAD LGRLTDADRD ALAALGVKLD IDLRTADEEA QSPDLLARDD
     RFDYQRISLM GTEKMDLQKM MTSFPDSLGE AYVQWLGHSQ PQFKQVFQRI AAQQDGAVLF
     HCTAGKDRTG IIAGLLLDLA GVPKAEIVHN YAISAHYLEG QPKDSDERAD HGAGQAEPGD
     RPQDGGHGRY RAGQHGAVLA ALHSQYGGAE GYLKSIGVSE QEIQQLKVRL GQAG