ID   IPI1_ASHGO              Reviewed;         338 AA.
AC   Q759I2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Pre-rRNA-processing protein IPI1;
GN   Name=IPI1; OrderedLocusNames=ADR306W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38803}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS52226.2; -; Genomic_DNA.
DR   RefSeq; NP_984402.2; NM_209755.2.
DR   AlphaFoldDB; Q759I2; -.
DR   SMR; Q759I2; -.
DR   STRING; 33169.AAS52226; -.
DR   EnsemblFungi; AAS52226; AAS52226; AGOS_ADR306W.
DR   GeneID; 4620568; -.
DR   KEGG; ago:AGOS_ADR306W; -.
DR   eggNOG; KOG2149; Eukaryota.
DR   HOGENOM; CLU_050252_2_0_1; -.
DR   InParanoid; Q759I2; -.
DR   OMA; CAGGWVK; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0006267; P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication; IEA:EnsemblFungi.
DR   GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..338
FT                   /note="Pre-rRNA-processing protein IPI1"
FT                   /id="PRO_0000308731"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   338 AA;  36839 MW;  369C88650B1FD2E7 CRC64;
     MAKKKTLKQQ DFQKKKLKVG KPKQAASNAT DTSFVAKTIH LPNQTKLTST NDAEADLLRR
     LSLCKHHSEI TRKETLIYLQ VAVPRVIHGQ VASRLMSACI PLMCDPNKHV REELLKLLDV
     VGSCDANTMR LYMRPLVLFM GSAMTHISAG VQRDSGRFLQ CVLRHAGHEL VRAAWVKMLR
     GLCNVLGWPL RGAASASAGA GSNVVSMHKN RALQHQNLQA LADFIRLGCA EPAAAALAGC
     AAPALYAKYL LPDCPQPYSH LKLFVREFPA DTAAAARPLH ELDTLVCEDA ATRRDVFLGH
     FRPVLAAQLP SLVKDGGDCG RVAANLLQLL DHVQQAAA