IPI1_ASPCL
ID IPI1_ASPCL Reviewed; 357 AA.
AC A1CMX6;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Pre-rRNA-processing protein ipi1;
GN Name=ipi1; ORFNames=ACLA_098550;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P38803}.
CC -!- SUBUNIT: Component of the RIX1 complex, composed of ipi1, rix1/ipi2 and
CC ipi3 in a 1:2:2 stoichiometry. The complex interacts (via rix1) with
CC mdn1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC particles. {ECO:0000250|UniProtKB:P38803}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38803}.
CC -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR EMBL; DS027058; EAW08913.1; -; Genomic_DNA.
DR RefSeq; XP_001270339.1; XM_001270338.1.
DR AlphaFoldDB; A1CMX6; -.
DR SMR; A1CMX6; -.
DR STRING; 5057.CADACLAP00008784; -.
DR PRIDE; A1CMX6; -.
DR EnsemblFungi; EAW08913; EAW08913; ACLA_098550.
DR GeneID; 4702305; -.
DR KEGG; act:ACLA_098550; -.
DR VEuPathDB; FungiDB:ACLA_098550; -.
DR eggNOG; KOG2149; Eukaryota.
DR HOGENOM; CLU_050252_2_0_1; -.
DR OMA; CAGGWVK; -.
DR OrthoDB; 1145058at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024679; Ipi1_N.
DR InterPro; IPR037947; TEX10/Ipi1.
DR PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR Pfam; PF12333; Ipi1_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..357
FT /note="Pre-rRNA-processing protein ipi1"
FT /id="PRO_0000308713"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 38068 MW; 53F0CD474E9EC59C CRC64;
MGSSAKKKKE KKKDFQKTKL RVGKTKAKPE NFTDTSFKAK SIVLNQQSLH ISAPSADAQF
THHLSLTSSK SDTQRRDSLA HLTTSIVSRP VDSPLPQPVS AILPTLLPLI LDASNGVRTQ
LLKLLRALPP ADVQDHVAQL LPYIRAGMTH LAADLRVSAV EVLAWLVDVA GAEVVACAGG
WIKTLNCFLS VLGWHTEESS KWSSSSSASV SASASATRAS FGKAGAQGKP MIKMLGALAE
FLQVGIGRPA EAAIGLDASD AEAGVAGWEF PLRHAAQHMV PRSSAPYIHL NLFGQPRDEE
GEMYETREDR YRVFASRFLG AVQRGLEGAR GEGGEVGRAS AGVSKVLKEA IAYGPGP
