IPI1_ASPFU
ID IPI1_ASPFU Reviewed; 345 AA.
AC Q4WCP8;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Pre-rRNA-processing protein ipi1;
GN Name=ipi1; ORFNames=AFUA_6G01990;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P38803}.
CC -!- SUBUNIT: Component of the RIX1 complex, composed of ipi1, rix1/ipi2 and
CC ipi3 in a 1:2:2 stoichiometry. The complex interacts (via rix1) with
CC mdn1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC particles. {ECO:0000250|UniProtKB:P38803}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38803}.
CC -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL85840.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHF01000012; EAL85840.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_747878.1; XM_742785.1.
DR AlphaFoldDB; Q4WCP8; -.
DR SMR; Q4WCP8; -.
DR STRING; 746128.CADAFUBP00009364; -.
DR GeneID; 3505330; -.
DR KEGG; afm:AFUA_6G01990; -.
DR VEuPathDB; FungiDB:Afu6g01990; -.
DR eggNOG; KOG2149; Eukaryota.
DR HOGENOM; CLU_050252_2_0_1; -.
DR InParanoid; Q4WCP8; -.
DR OrthoDB; 1145058at2759; -.
DR Proteomes; UP000002530; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024679; Ipi1_N.
DR InterPro; IPR037947; TEX10/Ipi1.
DR PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR Pfam; PF12333; Ipi1_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..345
FT /note="Pre-rRNA-processing protein ipi1"
FT /id="PRO_0000308714"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 37419 MW; 1204AE531A55B9B8 CRC64;
MGSSAKKKKE KKKDFQKTKL KVGKTKAKPD NFTDTSFRAK TITLNQQSLH ITAPSSDAQF
THHVSLLSSK SDTQRRDSLA HLTTSLVSRP VDSPLPQPVS VLLPTLLPLI LDASSSVRTQ
LLKLLRALPA NDIQDHVPQL LPYIRAGMTH LAADIRVSAV EVLSWLVDVA GAEVVSCAGG
WIKTLNCFLS VLGWHTEESS KWSGNRASFG KSGAKGQPMV KVLAALAVFL QAGIGRPDER
MDDSSDEDSA PGVSGWEFPL CHAAQHMVPQ ATAPFVHLNL FGQPRDEEGE MYETREDRYR
VFENRFLGAV QRGLESARGE GGEVGRASAG VSKVLKEAIA YGPGV