ID   IPI1_CANAL              Reviewed;         366 AA.
AC   Q59JU3; A0A1D8PSM0; Q5A6S9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Pre-rRNA-processing protein IPI1-1;
GN   Name=IPI1; OrderedLocusNames=CAALFM_CR03940WA;
GN   ORFNames=CaO19.379, CaO19.475, CaO19.8106;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38803}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31132.1; -; Genomic_DNA.
DR   RefSeq; XP_710023.2; XM_704931.2.
DR   AlphaFoldDB; Q59JU3; -.
DR   SMR; Q59JU3; -.
DR   STRING; 237561.Q59JU3; -.
DR   GeneID; 3648378; -.
DR   KEGG; cal:CAALFM_CR03940WA; -.
DR   CGD; CAL0000179551; orf19.8106.
DR   VEuPathDB; FungiDB:CR_03940W_A; -.
DR   eggNOG; KOG2149; Eukaryota.
DR   HOGENOM; CLU_050252_2_0_1; -.
DR   InParanoid; Q59JU3; -.
DR   OrthoDB; 1145058at2759; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..366
FT                   /note="Pre-rRNA-processing protein IPI1-1"
FT                   /id="PRO_0000308716"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   366 AA;  41001 MW;  C49F7405879CEDDA CRC64;
     MASKRKRKEK QKDFAKAKLK VGKTAQKPDN YTDTSFKSKT ISLPNQSIAS SSNYGASSGA
     SRSSLSTGPS LAVLTHQLSL TKHHSSNTRK EVLNYLQTHL PENPSYYKNI MTSILPLILD
     EDKEVRKALM SLLSAIFAKQ PGLIDLHLRS TILFILSAMS HIIPNIRTTS THFLRIIVEN
     SHGNLINSYF VKIMRNWFVL MGWSLNEQDS KQLSMAVTTL SITAMNANSK QARIGHLQNL
     NKFLSKTLQH DQDKDKNKDM KLNITIHPQS YKYLLTDTVQ PYQPLKLFVK EFKSEGSGSN
     GSGISMLDLN TISTEDLDTR KKIMNDVFKP LMIKNLNTFV KEGGEIGREA NNCISIVTQA
     CTSSSE