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IPI1_CHATD
ID   IPI1_CHATD              Reviewed;         338 AA.
AC   P0CT45;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Pre-rRNA-processing protein IPI1;
GN   Name=IPI1; ORFNames=CTHT_0115680;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38803}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR   EMBL; GL988039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0CT45; -.
DR   SMR; P0CT45; -.
DR   STRING; 759272.P0CT45; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..338
FT                   /note="Pre-rRNA-processing protein IPI1"
FT                   /id="PRO_0000425283"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   338 AA;  37390 MW;  812219A96F362661 CRC64;
     MGSSSKKKKE KQKDFQKPKL KVGKPKQKPS NFTDTSFKTK SIVVNQQTLT TEGLDSAELF
     KQNLTLAVNA KSDNQRRDAL AYVTNQLSAN PANNPVGTVG VLTKVLPLIT DGASSVRVQL
     LKLFRTLPPQ EVRPHAEKIL LYIRGGMTHL SNDVRTDTLN VLDWLLEVAG DEVVSCPGGW
     LKTLNSFSSM LGWNPNVSSA MTTKGWTSAP KATLGMKKGP ESQAKQIQVL AKFLQTGFRP
     EEPLPYKPRA YWDNIYRLPT TPNPFAYLNL FGLPRDEDSE MYPDRMSRLR VFDMKWRAAI
     TSGMETAKKE GGTVGRAAAI LDKALKASLE SDGSMQVN
 
 
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