ID   IPI1_DEBHA              Reviewed;         358 AA.
AC   Q6BLC4;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Pre-rRNA-processing protein IPI1;
GN   Name=IPI1; OrderedLocusNames=DEHA2F14608g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38803}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR   EMBL; CR382138; CAG89363.2; -; Genomic_DNA.
DR   RefSeq; XP_460997.2; XM_460997.1.
DR   AlphaFoldDB; Q6BLC4; -.
DR   SMR; Q6BLC4; -.
DR   STRING; 4959.XP_460997.2; -.
DR   EnsemblFungi; CAG89363; CAG89363; DEHA2F14608g.
DR   GeneID; 2903693; -.
DR   KEGG; dha:DEHA2F14608g; -.
DR   VEuPathDB; FungiDB:DEHA2F14608g; -.
DR   eggNOG; KOG2149; Eukaryota.
DR   HOGENOM; CLU_050252_2_0_1; -.
DR   InParanoid; Q6BLC4; -.
DR   OMA; CAGGWVK; -.
DR   OrthoDB; 1145058at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..358
FT                   /note="Pre-rRNA-processing protein IPI1"
FT                   /id="PRO_0000308719"
SQ   SEQUENCE   358 AA;  40342 MW;  CD287FAA5032F982 CRC64;
     MGSKRKKAEK QKDFVKAKLR VGKTAAKPDN HTDTSFIAKS ISIPNQTINK KTSNTEKKYE
     VDLAHHLSLT KHHSDVTRKE VLNYIEQHLP SNPSLYKDIL TSIVPLIIDQ SQNVRNALTS
     LLSACATQQV GLLDLHIRSI ILFIHSAMSH IKPDIRNSST KFLSVLIDHA TESLVRSYFI
     KTLKSYFTLL SWTLTNDKKA VSLAITTSSS IGGPSKKARI HHLSILRAFL SAALFPISSN
     ERKLDYSKIK MIHPESYKYL LASSTQPFAS LKLFVQEVPK QKNTDIQQNT KKDDNAFSLN
     DLDTVSTEDI DTRRKVMLDV FMAPMLRNLK NLIKEGGEVG REAHSCMKVL EQLQSETK