ID   IPI1_LODEL              Reviewed;         340 AA.
AC   A5E181;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Pre-rRNA-processing protein IPI1;
GN   Name=IPI1; ORFNames=LELG_03368;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38803}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR   EMBL; CH981527; EDK45189.1; -; Genomic_DNA.
DR   RefSeq; XP_001525440.1; XM_001525390.1.
DR   AlphaFoldDB; A5E181; -.
DR   SMR; A5E181; -.
DR   STRING; 379508.A5E181; -.
DR   PRIDE; A5E181; -.
DR   EnsemblFungi; EDK45189; EDK45189; LELG_03368.
DR   GeneID; 5232636; -.
DR   KEGG; lel:LELG_03368; -.
DR   VEuPathDB; FungiDB:LELG_03368; -.
DR   eggNOG; KOG2149; Eukaryota.
DR   HOGENOM; CLU_050252_2_0_1; -.
DR   InParanoid; A5E181; -.
DR   OMA; CAGGWVK; -.
DR   OrthoDB; 1145058at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..340
FT                   /note="Pre-rRNA-processing protein IPI1"
FT                   /id="PRO_0000308722"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   340 AA;  38238 MW;  760160DB092E21C9 CRC64;
     MGYKRKQKEK QKDFKKAKLK VGKTAKKPDN YTDTSFKAKT ISLPGQSISI VHGSKDFTHQ
     LSLLKHHSST TRKEVVINIT QNLPSNPAAY KLIISAAVPL ILDESKLVRT EVMNLLKEIG
     SKQPGLLDLH KRSIVLFIIS AMTHIQPDIR NTSTKFLATL LEYSDLKLYF VKILKNFFIL
     MSWSLLDDNK SKGVSITTNS TILLGPNTKK ARIDHLRVLV QFLKKNLLDD SEQGLVDADF
     SRIYTHPQTY KYLIPTTPQA FLALNLFGRE IKSDLSATGS IAIQNLDTMT TEDIETRLNI
     MNDIFKDRMI LNLKGLCKEG GEVGREASTC IDILEGISVK