ID   IPI1_NEOFI              Reviewed;         345 AA.
AC   A1DL11;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Pre-rRNA-processing protein ipi1;
GN   Name=ipi1; ORFNames=NFIA_048190;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of ipi1, rix1/ipi2 and
CC       ipi3 in a 1:2:2 stoichiometry. The complex interacts (via rix1) with
CC       mdn1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38803}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR   EMBL; DS027698; EAW15482.1; -; Genomic_DNA.
DR   RefSeq; XP_001257379.1; XM_001257378.1.
DR   AlphaFoldDB; A1DL11; -.
DR   SMR; A1DL11; -.
DR   STRING; 36630.CADNFIAP00005007; -.
DR   EnsemblFungi; EAW15482; EAW15482; NFIA_048190.
DR   GeneID; 4583893; -.
DR   KEGG; nfi:NFIA_048190; -.
DR   VEuPathDB; FungiDB:NFIA_048190; -.
DR   eggNOG; KOG2149; Eukaryota.
DR   HOGENOM; CLU_050252_2_0_1; -.
DR   OMA; CAGGWVK; -.
DR   OrthoDB; 1145058at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..345
FT                   /note="Pre-rRNA-processing protein ipi1"
FT                   /id="PRO_0000308724"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  37465 MW;  AFE88D4A6F5263B2 CRC64;
     MGSSTKKKKE KKKDFQKTKL KVGKTKAKPD NFTDTSFRAK TITLNQQSLH ITAPSSDAQF
     THHVSLLSSK SDTQRRDSLA HLTTSFVSRP VDSPLPQPVS VLLPTLLPLI LDASSSVRTQ
     LLKLLRALPA NDIQDHVPQL LPYIRAGMTH LAADIRVSAV EVLSWLVYVA GAEVVSCAGG
     WIKTLNCFLS VLGWHTEESS KWSGNRASFG KSGAKGQPMV KVLAALAVFL QAGIGRPDDG
     MGDSSDEDSA MGVSGWEFPL CHAAQHMVPQ ATAPFVHLNL FGQPRDEEGE MYETREDRYR
     VFENRFLRAV QRGLEGARSE GGEVGRASAG VSKVLKEAIA YGPGA