ID   IPI1_NEUCR              Reviewed;         352 AA.
AC   Q7SFQ6; V5INZ0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Pre-rRNA-processing protein ipi1;
GN   Name=rrm-9; Synonyms=ipi1; ORFNames=NCU09094;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of rrm-9/ipi1,
CC       rix1/ipi2 and ipi3 in a 1:2:2 stoichiometry. The complex interacts (via
CC       rix1) with mdn1 (via its hexameric AAA ATPase ring) and the pre-60S
CC       ribosome particles. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38803}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM002236; ESA43787.1; -; Genomic_DNA.
DR   EMBL; CM002236; ESA43788.1; -; Genomic_DNA.
DR   RefSeq; XP_011393234.1; XM_011394932.1.
DR   RefSeq; XP_011393235.1; XM_011394933.1.
DR   AlphaFoldDB; Q7SFQ6; -.
DR   SMR; Q7SFQ6; -.
DR   STRING; 5141.EFNCRP00000008690; -.
DR   EnsemblFungi; ESA43787; ESA43787; NCU09094.
DR   EnsemblFungi; ESA43788; ESA43788; NCU09094.
DR   GeneID; 3881035; -.
DR   KEGG; ncr:NCU09094; -.
DR   VEuPathDB; FungiDB:NCU09094; -.
DR   HOGENOM; CLU_050252_2_0_1; -.
DR   InParanoid; Q7SFQ6; -.
DR   OMA; CAGGWVK; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..352
FT                   /note="Pre-rRNA-processing protein ipi1"
FT                   /id="PRO_0000308725"
SQ   SEQUENCE   352 AA;  39036 MW;  A5AD6D160090E29A CRC64;
     MGSSNKKKKE KKKDFNKAKL KVGKAKAKAA NFTDTSFKSK SIVVNQHTLA ALDGVDLVGL
     FKQHLNQAIN SKSDKLRQEA LVQLTKDLSS KPIFNPVGVP NLLTKLLPLI TDSVANVRTN
     FLKLLRALPP SDVAPHVEKI LMYIRGGMTH LSTEIRSDTL SVLDWLIDVC PDETVSCPGG
     WLKTMNSFSS MLGWNPSVAS TLSVKGWTSA TKTSLNKVSK KNGEAQAKQI TTLAKFLEAG
     FRPETPLPYD EQRYWDSIYR MPTTPNPFAY LNLWGAQRDE DGEMYPDRIS RQQVFERKWR
     AAIKTGVMGA KQEGGVIGRA ASVLDKVLRT AEEGGKKVVE EQKIEEVEEA EA