ID   IPI1_PICST              Reviewed;         363 AA.
AC   A3M0B1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Pre-rRNA-processing protein IPI1;
GN   Name=IPI1; ORFNames=PICST_91441;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38803}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000502; ABN68682.2; -; Genomic_DNA.
DR   RefSeq; XP_001386711.2; XM_001386674.1.
DR   AlphaFoldDB; A3M0B1; -.
DR   SMR; A3M0B1; -.
DR   STRING; 4924.XP_001386711.2; -.
DR   EnsemblFungi; ABN68682; ABN68682; PICST_91441.
DR   GeneID; 4841157; -.
DR   KEGG; pic:PICST_91441; -.
DR   eggNOG; KOG2149; Eukaryota.
DR   HOGENOM; CLU_050252_2_0_1; -.
DR   InParanoid; A3M0B1; -.
DR   OMA; CAGGWVK; -.
DR   OrthoDB; 1145058at2759; -.
DR   Proteomes; UP000002258; Chromosome 8.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..363
FT                   /note="Pre-rRNA-processing protein IPI1"
FT                   /id="PRO_0000308727"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  40167 MW;  F83AB5EABA9A3526 CRC64;
     MATKRKKAQK AKDFVKPKLK VGKTAAKPDN HTDTSFTAKT ISLPNQSIAK KSKSGVSEEQ
     KQEIDLSHHL SLTKHHASAT RKEVLIYIDQ HLPSNPSLYK QIFTSIIPLI LDQSASVRTT
     LVALFNKCAN MQPGILELHI RSIALFIHSA MTHLHPEIRN SSTKFLNVLV EHAPQSLSKS
     FFVKTMRSYF TLMSWTLTDD KKSVSLAITT SAAIGGSVKK ARIGHLAVLK AFLQASLFPQ
     LSDSAESEIN PAIVVSVHPQ SYKYLIPAAT SQAFAPLKLF ANELPNNSKD IDDGKFHISD
     LDTITAEDLD TRRKVFVDVF QKPVVKNLNS LVKEGGEVGR EANSCMTIID NLEQELKKVA
     EDE